盐酸西替利嗪联合孟鲁司特钠治疗小儿喘息性支气管肺炎的效果及对炎性指标水平的影响  

Effect of Cetirizine Hydrochloride Combined with Montelukast Sodium in Children with Asthmatic Bronchopneumonia and Its Influence on the Level of Inflammatory Indicators

作　　者：袁艳 苏信斌 陆昊 YUAN Yan;SU Xinbin;LU Hao(Department of Pediatrics,Baiyun District People's Hospital,Guiyang,Guizhou Province,550014 China;Department of Laboratory,Guiyang Second People's Hospital,Guiyang,Guizhou Province,550081 China;Department of Laboratory,Baiyun District People's Hospital,Guiyang,Guizhou Province,550014 China)

机构地区：[1]贵阳市白云区人民医院儿科,贵州贵阳550014 [2]贵阳市第二人民医院检验科,贵州贵阳550081 [3]贵阳市白云区人民医院检验科,贵州贵阳550014

出　　处：《中外医疗》2024年第16期83-85,89,共4页China & Foreign Medical Treatment

摘　　要：目的 分析在小儿喘息性支气管肺炎患儿的治疗中应用盐酸西替利嗪联合孟鲁司特钠治疗效果。方法 随机选取2022年3月—2023年10月贵阳市白云区人民医院儿科收治的100例小儿喘息性支气管肺炎患儿为研究对象,根据治疗方式不同分为对照组与观察组,每组50例。对照组予孟鲁司特钠治疗,观察组在对照组的基础上加用盐酸西替利嗪进行治疗。比较两组临床疗效、不良反应、炎症指标、症状消失时间。结果 观察组临床疗效、症状消失时间优于对照组,差异有统计学意义(P均<0.05)。治疗后,观察组炎症指标水平低于对照组,差异有统计学意义(P<0.05)。观察组并发症发生率为4.00%,低于对照组的10.00%,但差异无统计学意义(χ^(2)=0.614, P>0.05)。结论 盐酸西替利嗪和孟鲁司特钠联合应用能提高药物的抗炎效果,能明显提高患儿的临床效果,减少患儿的炎性反应。Objective To analyze the therapeutic effect of cetirizine hydrochloride combined with montelukast sodium in the treatment of children with asthmatic bronchopneumonia.Methods A total of one hundred children with asthmatic bronchopneumonia treated in the Department of Pediatrics of Baiyun District People's Hospital of Guiyang City from March 2022 to October 2023 were randomly selected as the study objects.According to different treatment methods,they were divided into control group and observation group,with fifty cases in each group.The control group was treated with montelukast sodium,and the observation group was treated with cetirizine hydrochloride.The clinical efficacy,adverse reactions,inflammatory indicators and symptom disappearance time were compared between the two groups.Results The clinical efficacy and symptom disappearance time of the observation group were better than those of the control group,and the differences were statistically significant(all P<0.05).After treatment,the level of inflammation indexes in the observation group was lower than that in the control group,and the difference was statistically significant(P<0.05).The incidence of complications in the observation group was 4.00%,lower than that in the control group(10.00%),but the difference was not statistically significant(χ^(2)=0.614,P<0.05).Conclusion The combination of cetirizine hydrochloride and montelukast sodium can improve the anti-inflammatory effect of the drug,and can significantly improve the clinical effect and reduce the inflammatory response of the children.

关 键 词：盐酸西替利嗪 孟鲁司特钠 小儿喘息性支气管肺炎 

分 类 号：R4[医药卫生—临床医学]