IPS评分与单核细胞计数、降钙素原、C反应蛋白联合检测在脊柱创伤患者术后感染早期评估中的应用观察  

Application Value of IPS Combined with Monocyte Count,Procalcitonin and C-reactive Protein in Early Evaluation of Postoperative Infection in Patients with Spinal Trauma

作　　者：苏瑞龙 蔡弢艺[1] 吴采荣 徐维臻 郭长勇[1] SU Rui-long;CAI Tao-yi;WU Cai-rong;XU Wei-zhen;GUO Chang-yong(Department of Orthopaedics,The 909th Hospital(Dongnan Hospital of Xiamen University),Zhangzhou,Fujian,363000,China)

机构地区：[1]第九〇九医院(厦门大学附属东南医院)骨科,福建漳州363000

出　　处：《现代生物医学进展》2024年第11期2084-2087,2093,共5页Progress in Modern Biomedicine

基　　金：军事训练伤防治研究任务项目(21XLS23)。

摘　　要：目的:分析感染可能性评分(IPS)与单核细胞计数、降钙素原(PCT)、C反应蛋白(CRP)联合检测在脊柱创伤患者术后感染早期评估中的应用价值。方法:选取2016年3月~2023年10月期间医院收治行手术治疗的脊柱创伤术后感染患者31例为感染组,另选取同期收治脊柱创伤术后未发生感染患者31例为无感染组,比较两组患者IPS、单核细胞计数、PCT、CRP水平变化,Spearman相关性分析IPS、单核细胞计数、PCT、CRP相关性,受试者工作特征曲线(ROC)分析IPS、单核细胞计数、PCT、CRP及其联合时对脊柱创伤患者术后早期感染的评估价值。结果:感染组患者IPS、单核细胞计数、PCT、CRP水平均明显高于无感染组(P<0.05);Spearman相关性分析结果显示,IPS与单核细胞计数、PCT、CRP水平呈正相关(r=0.268、0.697、0.437,P<0.05)。ROC曲线分析结果显示,IPS、单核细胞计数、PCT、CRP联合预测患者术后感染的AUCROC为0.891高于各指标单独预测时的0.781、0.683、0.752、0.708。结论:四项指标联合检测可以提高脊柱创伤患者术后感染的预测价值。Objective:To analyze the application value of infection probability score(IPS)combined with monocyte count,procalcitonin(PCT)and C-reactive protein(CRP)in the early evaluation of postoperative infection in patients with spinal trauma.Methods:A total of 31 patients with infection and 31 patients without infection after spinal trauma surgery in the hospital were enrolled as infection group and non-infection group between March 2016 and October 2023,respectively.The changes of IPS,monocyte count,PCT and CRP in the two groups were compared.The correlation among IPS,monocyte count,PCT and CRP was analyzed by Spearman correlation analysis.The evaluation value of IPS,monocyte count,PCT,CRP and combined detection for postoperative infection in patients with spinal trauma was analyzed by receiver operating characteristic(ROC)curves.Results:IPS,monocyte count,PCT and CRP levels in infection group were significantly higher than those in non-infection group(P<0.05).The results of Spearman correlation analysis showed that IPS was positively correlated with monocyte count,PCT and CRP levels(r=0.268,0.697,0.437,P<0.05).The results of ROC curves analysis showed that AUCROC of IPS combined with monocyte count,PCT and CRP for predicting postoperative infection was 0.891,greater than that of single index(0.781,0.683,0.752,0.708).Conclusion:Combined detection of the four indexes can improve predictive value of postoperative infection in patients with spinal trauma.

关 键 词：脊柱创伤 术后感染 感染可能性评分 单核细胞计数 降钙素原 C反应蛋白 

分 类 号：R687.3[医药卫生—骨科学]