早卵泡期长效长方案联合全程重组黄体生成素对卵巢高反应人群排卵和妊娠结局的影响  

The Effect of Early Follicular Phase Long-acting Protocol Combined with Whole Process Recombinant Luteinizing Hormone on Ovulation and Pregnancy Outcomes of High Ovarian Response

作　　者：余晓燕[1] 杨惠林[1] 李燕子[1] 马英兰[1] 王春梅[2] 李琴[3] YU Xiao-yan;YANG Hui-lin;LI Yan-zi;MA Ying-lan;WANG Chun-mei;LI Qin(Reproductive Center,Qinghai Red Cross Hospital,Xining,Qinghai,810000,China;Gynecology Department,Qinghai Red Cross Hospital,Xining,Qinghai,810000,China;Department of Obstetrics and Gynecology,Qinghai University Affiliated Hospital,Xining,Qinghai,810000,China)

机构地区：[1]青海红十字医院生殖中心,青海西宁810000 [2]青海红十字医院妇科,青海西宁810000 [3]青海大学附属医院妇产科,青海西宁810000

出　　处：《现代生物医学进展》2024年第12期2341-2345,共5页Progress in Modern Biomedicine

基　　金：青海省卫生健康委员会指导性计划项目(2020-wjzdx-62)。

摘　　要：目的:探讨早卵泡期长效长方案联合重组黄体生成素(r-LH)对卵巢高反应人群排卵和妊娠结局的影响。方法:选入2019年1月~2023年3月在我院行早卵泡期长效长方案促排卵的卵巢高反应患者150例,根据是否添加r-LH分为对照组(未添加r-LH,n=75)和观察组(添加r-LH,n=75)。比较两组的促排卵相关指标和妊娠结局。结果:观察组Gn天数、Gn总量、HCG日血清LH水平、优质胚胎率均显著高于对照组,获卵数显著少于对照组(P<0.05)。两组降调天数、Gn启动量以及HCG日E2、P水平和子宫内膜厚度、临床妊娠率、活产率、流产率比较无差异(P>0.05)。结论:卵巢高反应患者行早卵泡期长效长方案促排卵时,添加r-LH可显著增加体内LH水平,提高优质卵泡率,对妊娠结局具有一定改善作用。Objective:To explore the effect of early follicular phase long-acting protocol combined with whole process recombinant luteinizing hormone(r-LH)on ovulation and pregnancy outcomes of high ovarian response.Methods:A total of 150 cases high ovarian response patients who underwent long-term ovulation induction in our hospital from January 2021 to March 2023 were divided into Matched group(r-LH was added,n=75)and observation group(r-LH was added,n=75 according to r-LH).Oovulation-related indicators and pregnancy outcomes were compared between the two groups.Results:Gn days,total Gn days,HCG daily serum LH level,and high-quality embryo rate were higher than that of the observation group,and the number of eggs obtained was less than that of the Matched group(P<0.05).There was no difference between the days of reduction,Gn initiation,E2,P level,and endometrial thickness,clinical pregnancy rate,live birth rate,and abortion rate between the two groups(P>0.05).Conclusion:The addition of r-LH significantly increased LH levels in vivo and improved the rate of high-quality follicles when ovulation was promoted in patients with ovarian hyperresponsiveness undergoing the early follicular phase of the long-acting,long-lasting regimen,which had an improved effect on pregnancy outcome.

关 键 词：卵巢高反应 长效长方案 早卵泡期 重组黄体生成素 排卵 妊娠结局 

分 类 号：R711.6[医药卫生—妇产科学]