溴系阻燃剂孕期暴露对子代发育毒性及作用机制的研究进展  

Research progress on the developmental toxicity and mechanism of brominated flame retardants during pregnancy exposure on offspring

作　　者：张磊 邹璟 李静 Zhang Lei;Zou Jing;Li Jing(Department of Pediatrics,Huai'an Hospital Affiliated to Xuzhou Medical University,Huai'an 223002,China;Department of Preventive Medicine,School of Public Health,Xuzhou Medical University,Xuzhou 221004,China)

机构地区：[1]徐州医科大学附属淮安医院儿科,淮安223002 [2]徐州医科大学公共卫生学院预防医学系,徐州221004

出　　处：《中华劳动卫生职业病杂志》2024年第6期468-474,共7页Chinese Journal of Industrial Hygiene and Occupational Diseases

基　　金：国家自然科学基金青年基金(81703260);江苏省普通高校研究生科研、实践创新计划(KYCX21_2725);江苏省青蓝工程项目(20220104);国家自然科学基金面上项目(82373609)。

摘　　要：溴系阻燃剂(brominated flame retardants,BFRs)是一类广泛用于电子电器、纺织、建筑材料等工业产品以提升阻燃性能的含溴化合物。由于其化学稳定性强,具有环境持久性、远距离传播性和生物蓄积性,目前母乳、血清及胎盘、脐带血中均可检测到BFRs。研究表明孕期暴露BFRs与多种不良出生结局如低体重、畸形、胎龄改变、神经行为发育损害有关。本文总结了三大传统BFRs,多溴二苯醚、六溴环十二烷、四溴双酚A的污染与人群暴露情况、孕期暴露对子代出生结局、生长发育的影响及作用机制,对BFRs孕期暴露对子代的危害进行探讨,为职业人群的预防措施提供参考。Brominated flame retardants(BFRs)are a kind of brominated compounds widely used in electronic and electrical appliances,textiles,construction materials and other industrial products to improve the flame retardant property.Because of its strong chemical stability,environmental persistence,long-distance transmission,biological accumulation,the exposure of humans and organisms in the ecosystem is increasing,and its potential biological effects are of great concern.Now BFRs can be detected in breast milk,serum,placenta and cord blood.Studies have shown that exposure to BFRs during pregnancy can lead to adverse birth outcomes such as low birth weight,malformation,gestational age changes and impairment of neurobehavioral development.This article summarizes the pollution and population exposure of three traditional BFRs,polybrominated diphenyl ethers(PBDEs),hexabromocyclododecane(HBCD),and tetrabromobisphenol A(TBBPA),as well as the impact and mechanism of prenatal exposure on offspring birth outcomes and growth and development.It explores the harm of prenatal exposure to BFRs to offspring and proposes preventive measures for occupational populations for reference.

关 键 词：火焰抑制剂 阻燃剂 溴系阻燃剂 多溴二苯醚 六溴环十二烷 四溴双酚A 孕期暴露 发育毒性 作用机制 

分 类 号：R114[医药卫生—卫生毒理学]