黏膜免疫佐剂及其在牙龈卟啉单胞菌疫苗中的应用  

Mucosal immune adjuvant and its application in Porphyromonas gingivalis vaccine

作　　者：王烁 李智涛[1] 万储宁 陈义祥 高社干[2] WANG Shuo;LI Zhitao;WAN Chuning;CHEN Yixiang;GAO Shegan(College of Basic Medicine and Forensic Medicine,Henan University of Science and Technology,Luoyang 471000;The First Afiliated Hospital of Henan University of Science and Technology,Luoyang 471000,China)

机构地区：[1]河南科技大学基础医学与法医学院,河南洛阳471000 [2]河南科技大学第一附属医院,河南洛阳471000

出　　处：《生物技术》2024年第3期395-402,共8页Biotechnology

基　　金：河南省科技攻关重点项目(222102310300);河南省高等学校重点科研项目(22A310014)。

摘　　要：病原体的感染通常从黏膜侵入机体,因此黏膜免疫是保护机体免受病原侵犯的重要策略之一。牙龈卟啉单胞菌(Porphyromonas gingivalis,Pg)的感染起始于牙龈黏膜表面,激活局部黏膜免疫应答是预防Pg感染的有效途径。为了增强疫苗的黏膜免疫效果,往往需要添加黏膜免疫佐剂。该文综述了近年来黏膜免疫佐剂的研究进展,归纳总结了不同类型黏膜免疫佐剂作用机制、优缺点以及在Pg疫苗中应用现状和效果。此外,探讨了黏膜免疫佐剂在Pg疫苗中潜在的应用价值和发展趋势,为Pg疫苗的研发和佐剂的选择提供新思路。The infection of pathogens usually invades the body from the mucosa,so mucosal immunity is one of the important strategies to protect the body from pathogens.Porphyromonas gingivalis(Pg)infection originates from the gingival mucosal surface,so activating the local mucosal immune response is an effective approach to prevent Pg infection.In order to enhance the mucosal immune effect of vaccines,mucosal immune adjuvants are needed.In this review,the recent progress in mucosal immune adjuvant was outlined.The mechanisms,advantages,and disadvantages of different types of mucosal immune adjuvants,as well as their current applications and effects in Pg vaccine were summarized.In addition,the potential application value and developmental trends of mucosal immune adjuvants in Pg vaccine were discussed.This review provides new perspectives for the development of Pg vaccine and the selection of adjuvants.

关 键 词：牙龈卟啉单胞菌 黏膜免疫 疫苗 免疫佐剂 

分 类 号：R186.3[医药卫生—流行病学]