苯生物监测指标测定方法的研究进展  

Research progress in determination methods of benzene biological monitoring indicators

作　　者：何宗剑 莫玉茗 HE Zongjian;MO Yuming(Department of Physical and Chemical Testing,Guangxi Zhuang Autonomous Region Academy for Prevention and Treatment of Occupational Diseases,Nanning Guangxi,530021,China;School of Public Health,Guangxi Medical University,Nanning Guangxi,530021,China)

机构地区：[1]广西壮族自治区职业病防治研究院理化检测所,广西南宁530021 [2]广西医科大学公共卫生学院,广西南宁530021

出　　处：《职业与健康》2024年第10期1426-1429,共4页Occupation and Health

基　　金：广西壮族自治区卫生健康委员会课题(Z-A20230412)。

摘　　要：苯是一种被广泛使用的化工原料和环境污染物,具有致癌性和血液毒性。急性苯中毒会引发神经中枢系统麻痹等症状甚至是DNA链的损伤。慢性苯中毒会造成白细胞减少、骨髓抑制、神经衰弱综合征,严重时能导致再生障碍性贫血及白血病。尿中苯的代谢物反,反-粘糠酸和苯巯基尿酸是苯的生物监测指标,其测定方法有多种。本文综述了近年来国内外尿中反,反-粘糠酸和苯巯基尿酸测定方法的研究进展,比较不同方法的优缺点,并对测定方法的发展前景进行展望。Benzene is a widely used chemical raw material and environmental pollutant,which has carcinogenic and blood toxicity.The acute benzene poisoning can cause symptoms such as paralysis of the central nervous system and even damage to DNA strands.The chronic benzene poisoning can cause leukopenia,bone marrow suppression,neurasthenia syndrome,and in severe cases,aplastic anemia and leukemia.The metabolites of benzene in urine,trans,trans-muconic acid and phenylmercaptouric acid,are biological monitoring indicators of benzene,and there are various methods for their determination.The paper reviews the research progress in the determination of trans,trans-muconic acid and phenylmercaptouric acid in urine at home and abroad in recent years,compares the advantages and disadvantages of dfferent methods,and prospects the development prospects of the determination methods.

关 键 词：苯 生物监测指标 反 反-粘糠酸 苯巯基尿酸 研究进展 

分 类 号：R115[医药卫生—公共卫生与预防医学]