精准医学时代的华西生物样本库建设现状及未来展望  

The current status and future prospects of the establishment of West China Biobank in the era of precision medicine

作　　者：谭维维[1] 李淑君 樊萍[1] 姜兰 陈蕾[2] 黄伟[1,3] TAN Weiwei;LI Shujun;FAN Ping;JIANG Lan;CHEN Lei;HUANG Wei(West China Biobank,West China Hospital,Sichuan University,Chengdu 610041,China;Department of Neurology,West China Hospital,Sichuan University,Chengdu 610041,China;West China Centre of Excellence for Pancreatitis,Institute of Integrated Traditional Chinese and Western Medicine,West China-Liverpool Biomedical Research Centre,West China Hospital,Sichuan University,Chengdu 610041,China)

机构地区：[1]四川大学华西医院生物样本库,成都610041 [2]四川大学华西医院神经内科,成都610041 [3]四川大学华西医院中西医结合中心,华西-利物浦生物医学研究中心,胰腺炎中心,成都610041

出　　处：《中国科学：生命科学》2024年第6期1050-1060,共11页Scientia Sinica(Vitae)

摘　　要：生物样本库是生物医学研究的基础设施,是促进医疗创新以实现精准医学的关键环节,也是符合国家医学中心建设的医疗创新战略资源平台.中国生物样本库建设与欧美和其他发达国家相比起步较晚,整体发展水平相对滞后,目前只有少数顶级研究型医院发展水平较高,大部分生物样本库缺乏“临床-科研型领军人才”,欠缺对“生物样本学”学科的深入认识,导致其发展规模、质量、水平参差不齐.因此,亟待建立大规模、规范化、高质量的生物样本库以及支撑其发展的学科体系,推动研究型医院及其联盟医院的建设,进而提升中国医疗创新能力.本文分析了国内外生物样本库发展的特点,并以四川大学华西医院生物样本库为例,阐述了该团队对“生物样本学”学科建设的认识和理念,并总结其在临床研究中的支撑作用和应用方向,提出以有组织地解决重大临床科学问题为导向的国家医学中心医疗创新战略资源平台建设的方案.最后,笔者就目前华西生物样本库建设的不足之处提出建议,也对未来发展的规划进行展望.Biobanks represent critical pillars of infrastructure within the biomedical research landscape,essential for propelling advancements in precision medicine and fostering medical breakthroughs.Their role as strategic resource repositories is instrumental in aligning with the objectives set forth for the development of national-level medical centers.In China,the inception and progression of biobanking have trailed behind those of more established counterparts in Europe,America,and other developed nations.Presently,only a handful of research hospitals in China boast significant advancements in this field,while the majority of biobanks encounter challenges stemming from a shortage of requisite clinical and scientific expertise,compounded by a limited understanding of“biobanking”as an academic discipline in its own right.These challenges contribute to disparities in the scale,quality,and standards of biobank development across the country.Addressing these challenges necessitates the establishment of large-scale,standardised,and highquality biobanks,coupled with the development of supportive academic frameworks.Such initiatives are vital for enhancing the construction of research hospitals and associated networks,thereby bolstering China’s capabilities in medical innovation.This paper analyses the development traits of biobanks on both domestic and international fronts,with the biobank at West China Hospital of Sichuan University serving as an illustrative case.It delves into the team’s insights and conceptualisations regarding the academic construction of“biobanking”,detailing its supportive function and application directions in clinical research.Furthermore,it proposes a construction strategy for a national-level medical center as a strategic resource platform oriented towards addressing significant clinical and scientific issues in biobanking.In conclusion,the authors offer recommendations for enhancing the current biobank infrastructure at West China and provide a forecast for its future developmental t

关 键 词：生物样本库 生物样本学 医疗创新战略资源平台 精准医学 临床研究 

分 类 号：R318[医药卫生—生物医学工程]