105例隐性梅毒患者早期感染情况调查分析  

Investigation and analysis on early infection in 105 cases of latent syphilis

作　　者：何婉苹 彭嘉俊 杨韵青 彭丽倩 王焕丽 罗权 叶兴东 王建琴 HE Wan-ping;PENG Jia-jun;YANG Yun-qing;PENG Li-qian;WANG Huan-li;LUO Quan;YE Xing-dong;WANG Jian-qin(Preventive and Health Care Department,Guangzhou Dermatology Hospital,Guangdong510095,China;STD Preventionand Treatment Department,Guangzhou Dermatology Hospital;Guangzhou Dermatology Hospital;Medical Department,Guangzhou Dermatology Hospital)

机构地区：[1]广州市皮肤病医院预防保健科,广东510095 [2]广州市皮肤病医院性病防治科 [3]广州市皮肤病医院 [4]广州市皮肤病医院医务科

出　　处：《预防医学论坛》2024年第4期272-275,共4页Preventive Medicine Tribune

基　　金：广东省广州市医药卫生科技重大项目(20181A031003);广东省广州市科技计划项目(2024A03J0650)。

摘　　要：目的 对105例隐性梅毒患者早期感染情况进行调查分析,为制定有针对性的防控措施提供科学依据。方法 用方便抽样法,选取2022年广东省人民医院、南方医科大学附属第三医院、广州市皮肤病医院、广州市白云区妇幼保健院确诊报告的105例隐性梅毒患者为调查对象。收集病例的一般人口学特征、性行为特征及病史、梅毒和HIV实验室检测信息,分析不同特征隐性梅毒患者的特征及早期感染情况。结果 共调查隐性梅毒患者105例,74.29%(78/105)由皮肤性病科确诊报告,25.71%(27/105)由非皮肤性病科确诊报告;80.95%(85/105)为门诊主动就诊者,19.05%(20/105)为住院筛查阳性病例。男性占56.19%(59/105),女性占43.81%(46/105);在婚占48.57%(51/105),单身(包括未婚、离异或丧偶)占51.43%(54/105)。快速血浆反应素环状卡片试验(RPR)或甲苯胺红不加热血清试验(TRUST)滴度<1∶8占54.81%(57/104),滴度≥1∶8占45.19%(47/104)。45.71%(48/105)为早期隐性梅毒。早期感染的比例,皮肤性病科高于非皮肤性病科(χ^(2)=8.083,P=0.004),门诊主动就诊者高于住院被动筛查者(χ^(2)=4.272,P=0.039),男性高于女性(χ^(2)=7.702,P=0.006),单身人群高于在婚人群(χ^(2)=4.339,P=0.037),20~29岁高于其他年龄段(χ^(2)=19.379,P<0.001),最近2年内有非婚性伴者高于无非婚性伴者(χ^(2)=7.430,P=0.006),RPR/TRUST滴度≥1∶8者高于<1∶8者(χ^(2)=16.597,P<0.001)。结论 该105例隐性梅毒患者早期感染的比例较高,人群传播风险较大。Objective To understand the prevalence and related factors of early latent syphilis in Guangzhou city,so as to provide scientific basis for formulating targeted prevention and control measures.Methods Using convenience sampling method,105cases of latent syphilis confirmed and reported by Guangdong Provincial People's Hospital,the Third Affiliated Hospital of Southern Medical University,Guangzhou Dermatological Hospital,and Baiyun District Maternal and Child Healthcare Hospital of Guangzhou City in 2022were selected for the survey.The general demographic characteristics,sexual behavior characteristics,medical history,and laboratory testing information of syphilis and HIV were collected.The characteristics and early infection status of individuals with different latent syphilis characteristics were analyzed.Results A total of 105cases of latent syphilis were investigated,of which 74.29%(78/105)were confirmed by cutaneous venereal departments,and 25.71%(27/105)were confirmed by non cutaneous venereal departments,80.95%(85/105)of the cases were active visitors to the outpatient services,and 19.05%(20/105)were screened for syphilis positively from the inpatient departments.The male accounted for 56.19%(59/105)and the female accounted for 43.81%(46/105).The proportion of the being married were 48.57%(51/105),while that of the singles including the unmarried,divorcees and widows were 51.43%(54/105).Rapid plasma reactin ring card test(RPR)or toluidine red unheated serum test(TRUST)had a titre<1∶8in 54.81%(57/104)and a titre≥1∶8in 45.19%(47/104).Of the 105cases,45.71%(48/105)were early latent syphilis.The percentage of early infection were higher in cutaneous venereal departments(χ^(2)=8.083,P=0.004),active outpatient patients(χ^(2)=4.272,P=0.039),the male(χ^(2)=7.702,P=0.006),singles(χ^(2)=4.339,P=0.037),people aged 20-29years old(χ^(2)=19.379,P<0.001),the ones having unmarried sexual partners within the past 2years(χ^(2)=7.430,P=0.006)and having RPR or TRUST titer≥1:8(χ^(2)=16.597,P<0.001),compared to non

关 键 词：隐性梅毒 性病 早期感染 

分 类 号：R759.14[医药卫生—皮肤病学与性病学] R195.4[医药卫生—临床医学]