中药七情“相恶”配伍的历史变迁及现代研究进展  

Historical changes and modern research progress of the mutual inhibition of compatibility among seven relations in Chinese medicine

作　　者：张瑞欣 杨志军 杨秀娟 黄蓉 崔彦红 李一洁 ZHANG Ruixin;YANG Zhijun;YANG Xiujuan;HUANG Rong;CUI Yanhong;LI Yijie(College of Pharmacy,Gansu University of Chinese Medicine,Lanzhou,Gansu,730101,China;Gansu Key Laboratory of Pharmacology and Toxicology of Chinese Medicine,Lanzhou,Gansu,730000,China)

机构地区：[1]甘肃中医药大学药学院,甘肃兰州730101 [2]甘肃省中药药理与毒理学重点实验室,甘肃兰州730000

出　　处：《甘肃中医药大学学报》2024年第3期88-92,共5页Journal of Gansu University of Chinese Medicine

基　　金：甘肃省中医药管理局科研基金资助项目(GZK-2019-20);甘肃省教育厅高等教育教学成果培育项目(2020-120);甘肃中医药大学“课程思政”示范课建设项目(2020-3,2021-5);校级教学研究与教学改革课题(YB-201705,YBXM-02);教育厅高等教育教学成果培育项目(2023-110)。

摘　　要：查阅相关文献,从相恶内涵的沿革考证、相恶配伍临床应用、相恶药对的研究概况等3个方面对中药七情之“相恶”配伍进行概述。发现相恶内涵在历代本草中存在药效制约与毒性制约2种不同观点,目前普遍认为相恶是二药合用后,一种药物的某一种功效被另一种药物削弱。然而,相恶配伍在经方及现代临床中却有一定应用,且疗效显著。通过现代研究,发现相恶药对拮抗减效与药物炮制、配伍比例、组方中其他药物作用等有一定关联性。因此,相恶配伍是临床可用的一种特殊配伍关系,应辨证配伍,合理应用。This article summarizes the mutual inhibition of Chinese medicine compatibilityamong seven relations in Chinese medicine by referencing relevant literature,focusing on historical research of its connotation,clinical applications,and the drug compatibility studies.It is noted that there are two different views on the mutual inhibition of Chinese medicine compatibility in the history:efficacy restriction and toxicity restriction.While it is generally believed that the mutual inhibitionof Chinese medicine compatibility weakens the effect of one another after combination of two drugs,it has shown remarkable effects in prescription and modern clinical practice.Modern research indicates that mutual inhibitionis correlated with drug processing,compatibility ratio,and other drugs in formulations.Therefore,he mutual inhibition is a special relationship that can be used clinically and should be applied rationally based on syndrome differentiation.

关 键 词：中药七情 相恶 配伍 历史变迁 现代研究 综述 

分 类 号：R289.1[医药卫生—方剂学]