左旋肉碱在卵母细胞成熟和早期胚胎发育中的生物学作用  

Biological function of L-carnitine in oocyte maturation and early embryo development

作　　者：孙理兰[1] 孙平平[1] 赵文杰[1] 马华刚[1] Sun Lilan;Sun Pingping;Zhao Wenjie;Ma Huagang(Center of Reproductive Medicine,Weifang People's Hospital,Weifang 261000,China)

机构地区：[1]潍坊市人民医院生殖医学中心,潍坊261000

出　　处：《中华生殖与避孕杂志》2024年第6期661-665,共5页Chinese Journal of Reproduction and Contraception

摘　　要：卵母细胞质量差是导致女性不孕的主要原因之一, 寻找改善卵母细胞质量的调节剂越来越受到重视。目前已有大量研究表明左旋肉碱在调节女性生殖能力方面具有重要功能。鉴于此, 本文综述了左旋肉碱在卵母细胞成熟和早期胚胎发育中的关键作用及其调控机制, 包括活化脂肪酸进行β-氧化来调节能量代谢、抗氧化防止氧化损伤和抑制细胞凋亡等, 及左旋肉碱在改善卵母细胞质量和早期胚胎发育中的研究进展。Poor oocyte quality is responsible for female infertility.The search for supplements to improve oocyte quality is receiving increasing attention.Many studies have shown that L-carnitine plays a variety of roles in regulating female fertility.This article reviews the key roles and regulatory mechanisms of L-carnitine in oocyte maturation and early embryonic development,including activating fatty acids for β-oxidation to regulate energy metabolism,antioxidation to prevent oxidative damage,and inhibition of cell apoptosis,and the research progress of LC in improving oocyte quality and early embryo development.

关 键 词：左旋肉碱 卵母细胞 脂质代谢 抗氧化 凋亡 胚胎 

分 类 号：R321[医药卫生—人体解剖和组织胚胎学]