老年慢性阻塞性肺疾病患者血清DPP4、ADAM33、ANXA2水平与病情程度及预后的关系  

Relationship of serum levels of DPP4,ADAM33,and ANXA2 with the severity and prognosis of chronic obstructive pulmonary disease in elderly patients

作　　者：马利 李茉 马晓瑞 Ma Li;Li Mo;Ma Xiaorui(Department of General Medicine,Xi′an No.9 Hospital,Xi′an 710000,China)

机构地区：[1]西安市第九医院全科医学科,西安710000

出　　处：《国际呼吸杂志》2024年第6期676-682,共7页International Journal of Respiration

基　　金：陕西省自然科学基础研究计划项目(2020JQ-960)。

摘　　要：目的探究老年慢性阻塞性肺疾病(慢阻肺)患者血清二肽基肽酶4(DPP4)、解整合素-金属蛋白酶33(ADAM33)、膜联蛋白A2(ANXA2)水平与病情程度及预后的关系。方法本研究为队列研究。采用非随机抽样法,选取2020年3月至2023年至3月在西安市第九医院治疗的250例慢阻肺患者作为研究组,根据慢性阻塞性肺疾病全球创议肺功能分级将慢阻肺患者分为Ⅰ~Ⅳ级。根据患者预后情况分为预后良好组和预后不良组。另选取同期健康体检者250名作为对照组。酶联免疫吸附试验检测DPP4、ADAM33、ANXA2水平;肺功能仪检测肺功能;Pearson法分析血清DPP4、ADAM33、ANXA2与肺功能指标的相关性;慢阻肺患者预后不良的影响因素采用logistic回归分析;绘制受试者操作特征曲线分析血清DPP4、ADAM33、ANXA2对慢阻肺患者预后不良的预测价值。结果研究组250例,男170例,女80例,年龄(65.50±2.26)岁;对照组250名,男168名,女82名,年龄(65.39±2.18)岁,2组性别、年龄比较差异无统计学意义(χ^(2)=0.037,t=0.554,均P>0.05)。研究组血清DPP4、ADAM33、ANXA2水平高于对照组[(451.29±20.06)μg/L比(386.57±19.84)μg/L,(38.24±3.87)ng/L比(18.59±2.45)ng/L,(32.56±3.31)μg/L比(16.48±2.51)μg/L,t值分别为36.27、67.83、61.21,均P<0.05],第1秒用力呼气容积占预计值百分比(FEV 1%pred)、第1秒用力呼气容积(FEV 1)/用力肺活量(FVC)和PEF低于对照组[(58.82±5.86)%比(90.24±8.72)%,(57.60±2.25)%比(83.94±3.67)%,(5.97±1.28)L/s比(8.61±1.30)L/s,t值分别为47.29、96.75、22.88,均P<0.05]。Ⅰ~Ⅳ级慢阻肺患者血清DPP4、ADAM33、ANXA2水平依次升高(均P<0.05),FEV 1%pred、FEV 1/FVC和PEF依次降低(均P<0.05)。根据Pearson相关性分析得知,血清DPP4、ADAM33、ANXA2与FEV 1%pred、FEV 1/FVC、PEF均有关(均P<0.05)。预后不良组血清DPP4、ADAM33、ANXA2水平高于预后良好组[(569.66±21.30)μg/L比(410.56±19.64)μg/L,(57.61±4.26)ng/L比(31.58±3.74)ng/L,(49.14±3.51)μg/ObjectiveTo explore the relationship of serum levels of dipeptidyl peptidase 4(DPP4),a disintegrin and metalloprotease 33(ADAM33),and annexin A2(ANXA2)with the severity and prognosis of chronic obstructive pulmonary disease(COPD)in elderly patients.MethodsThis was a cohort study.Using non-random sampling,250 COPD patients treated in the Ninth Hospital of Xi′an from March 2020 to March 2023 to March 2023 were enrolled as the study subjects and classified into grades I to IV according to global initiative for chronic obstructive lung disease.According to the prognosis of the patients,they were divided into good prognosis and poor prognosis groups.Another 250 healthy individuals who underwent physical examinations during the same period were enrolled as the control group.ELISA was applied to detect levels of DPP4,ADAM33,and ANXA2.Pulmonary function meter was applied to detect lung function.Pearson method was used to analyze the correlation between serum DPP4,ADAM33,ANXA2 and lung function indicators.Logistic regression was used to analyze the influencing factors of poor prognosis in COPD patients.Receiver operator characteristic curve was plotted to analyze the predictive value of serum DPP4,ADAM33,and ANXA2 for poor prognosis in COPD patients.ResultsThere were 250 cases in the study group,170 males and 80 females,with a mean age of(65.50±2.26)years old,and 250 cases in the control group,168 males and 82 females,with a mean age of(65.39±2.18)years old.There was no statistical significance in the gender and age between the two groups(χ^(2)=0.037,t=0.554,all P>0.05).Serum DPP4,ADAM33 and ANXA2 levels in the study group were significantly higher than those in the control group([451.29±20.06]μg/L vs[386.57±19.84]μg/L,[38.24±3.87]ng/L vs[18.59±2.45]ng/L,[32.56±3.31]μg/L vs[16.48±2.51]μg/L,t=36.27,67.83,61.21,respectively,all P<0.05),and FEV 1%pred,FEV 1/FVC,and PEF were significantly lower than those in the control group([58.82±5.86]%vs[90.24±8.72]%,[57.60±2.25]%vs[83.94±3.67]%,[5.97±1.28]L/s vs[8.61�

关 键 词：肺疾病 慢性阻塞性 二肽基肽酶4 解整合素-金属蛋白酶33 膜联蛋白A2 病情程度 预后 

分 类 号：R563.9[医药卫生—呼吸系统]