酰基辅酶A在疾病中的代谢调控  

The Metabolic Regulation of Acyl Coenzyme A in Diseases

作　　者：郭萌皓 丁俊[2] 黄赞[1] GUO Menghao;DING Jun;HUANG Zan(College of Life Sciences,Wuhan University,Wuhan 430072,China;Characteristic Agricultural Resources Plant Research Center,Wuhan Botanical Garden,Chinese Academy of Sciences,Wuhan 430074,China)

机构地区：[1]武汉大学生命科学学院,湖北武汉430072 [2]中国科学院武汉植物园特色农业资源植物研究中心,湖北武汉430074

出　　处：《生物化工》2024年第3期158-163,共6页Biological Chemical Engineering

摘　　要：酰基辅酶A是脂质代谢的中间体,参与脂肪酸合成和降解、转录因子活化、蛋白质翻译后修饰以及能量代谢等一系列代谢途径,在生物体的生命活动中发挥着重要作用。当酰基辅酶A发生紊乱时,会影响生物体的各种生理和病理过程,进而引起各种疾病如肝细胞癌、糖尿病和心脏病等。因此,了解酰基辅酶A在这些疾病中的代谢功能对于临床靶向治疗有指导性意义。本文将从酰基辅酶A的结构和分类、参与代谢通路、酰基辅酶A在一些常见疾病中的代谢调控等方面进行综述,并对今后酰基辅酶A在疾病的临床靶向治疗方面的应用进行展望。Acyl coenzyme A(acyl-CoA)is an intermediate of lipid metabolism and is involved in a number of metabolic pathways,such as fatty acid synthesis and degradation,transcription factor activation,post-translational modification of proteins,and energy metabolism,which plays an important role in the life activities of organisms.The dysregulation of acyl-CoA will affect various physiological and pathological processes in organisms,leading to a variety of diseases such as hepatocellular carcinoma,diabetes mellitus,and heart disease.Therefore,understanding the metabolic function of acyl-CoA in these diseases is instructive for clinically targeted therapy.In this review,we will present the structure and classification of acyl-CoA,the metabolic pathways involved,the metabolic regulation of acyl-CoA in some common diseases,and discuss the potential of utilizing acyl-CoA as a clinical target in the future therapy.

关 键 词：酰基辅酶A 脂肪酸代谢 疾病代谢 靶向治疗 

分 类 号：Q552[生物学—生物化学] Q591.5