乌苏烷型五环三萜类化合物抗肿瘤研究进展  

Research Progress in the Anti-Tumor Research of Ursane Pentacyclic Triterpenoids

作　　者：陈子明 吴天惠 刘欣 王兆博 郭伟强[1] 刘恒蔚[1] CHEN Ziming;WU Tianhui;LIU Xin;WANG Zhaobo;GUO Weiqiang;LIU Hengwei(School of Chemistry and Life Sciences,Suzhou University of Science and Technology,Suzhou 215009,China)

机构地区：[1]苏州科技大学化学与生命科学学院,江苏苏州215009

出　　处：《生物化工》2024年第3期189-194,共6页Biological Chemical Engineering

基　　金：国家自然科学基金(81502958);江苏省研究生创新创业计划(KYCS22_3295)。

摘　　要：乌苏烷型五环三萜类化合物在植物中广泛存在,来源丰富,甘草、枇杷叶、苹果等含量较高。药理学研究表明此类化合物具有抗肿瘤、抗氧化、抗炎等生物活性,具有较大的医用价值和开发潜力。因此,本文针对近年来国内外有关乌苏烷型五环三萜类化合物抗肿瘤活性和作用机制的文献报道进行梳理,以期对此类化合物的进一步研究和抗肿瘤应用开发提供参考。Ursane pentacyclic triterpenoids are widely present in the natural plant kingdom and have abundant sources.They have a high content in plants such as licorice,loquat leaves,apples,etc.Pharmacological studies have shown that such compounds have biological activities such as anti-tumor,antioxidant,anti-inflammatory,and have lower toxic side effects,which has great medical value and development potential.This article reviews the literature reports on the anti-tumor activity and mechanism of action of ursane pentacyclic triterpenoids both domestically and internationally in recent years,in order to provide reference for further research and development of anti-tumor applications of these compounds.

关 键 词：乌苏烷型五环三萜 抗肿瘤 作用机制 

分 类 号：R965[医药卫生—药理学]