壳聚糖抗菌复合骨修复材料的研究进展  

Research Progress of Chitosan Antibacterial Composite Bone Repair Materials

作　　者：康董青 王子凡 李智颖 KANG Dongqing;WANG Zifan;LI Zhiying(Biomedical Research Center,Northwest Minzu University,Lanzhou 730030,China;School of Chemical Engineering,Northwest Minzu University,Lanzhou 730030,China;National Joint Laboratory of China and Malaysia,Northwest Minzu University,Lanzhou 730030,China;Key Laboratory of Biotechnology and Bioengineering of State Ethnic Affairs Commission,Biomedical Research Center,Northwest Minzu University,Lanzhou 730030,China)

机构地区：[1]西北民族大学生物医学研究中心,甘肃兰州730030 [2]西北民族大学化工学院,甘肃兰州730030 [3]西北民族大学中国与马来西亚国家联合实验室,甘肃兰州730030 [4]西北民族大学生物医学研究中心国家民族委员会生物技术与生物工程重点实验室,甘肃兰州730030

出　　处：《生物化工》2024年第3期229-235,共7页Biological Chemical Engineering

基　　金：甘肃省自然科学基金项目(23JRRA718);中央高校基本科研业务费专项资金项目(31920220133)。

摘　　要：随着生物医用材料性能要求的提高,壳聚糖及其复合材料在骨组织工程中得到了广泛的应用和研究。壳聚糖作为一种天然的生物高分子基材料,具有良好的生物相容性、生物降解性和生物活性,已成为骨修复材料的重要组成部分。为了提高壳聚糖骨修复材料的抗菌性能和生物活性,研究者采用多种方法将壳聚糖与其他材料复合。其中,壳聚糖复合银纳米粒子、生物活性玻璃、羟基磷灰石等材料能有效提高壳聚糖材料的抗菌性能,促进骨细胞增殖和再生。本文综述了壳聚糖复合抗菌材料在骨组织工程(软骨损伤、骨折、口腔)中的最新应用进展,分析了其发展中面临的挑战。With the improvement of the performance requirements of biomedical materials,chitosan and its composites had been widely used and studied in bone tissue engineering.As a natural biopolymer-based material,chitosan has good biocompatibility,biodegradability,and biological activity and has became an essential component of bone repair materials.In order to improve the antibacterial properties and biological activity of chitosan bone repair materials,researchers have used various methods to composite chitosan with other materials.Among them,chitosan composite silver nanoparticles,bioactive glass,hydroxyapatite,and other materials can effectively improve chitosan materials’antibacterial properties and promote bone cell proliferation and regeneration.This article reviews the latest progress and application of chitosan composite antibacterial materials in bone tissue engineering(cartilage injury,fracture,and oral cavity)and analyzes the challenges and shortcomings in its development.

关 键 词：骨缺损 抗菌材料 壳聚糖 

分 类 号：O629[理学—有机化学]