终末期肾病患者脑网络动态功能连接  

Dynamic functional connectivity of brain networks in end-stage renal disease patients

作　　者：乔雅倩 王玉龙 白培瑞 王成健 任延德[1] 毕玉珍 QIAO Yaqian;WANG Yulong;BAI Peirui;WANG Chengjian;REN Yande;BI Yuzhen(Department of Medical imaging,the Affiliated Hospital of Qingdao University,Qingdao 266100,China;School of Electronic Information Engineering,Shandong University of Science and Technology,Qingdao 266400,China)

机构地区：[1]青岛大学附属医院放射科,山东青岛266100 [2]山东科技大学电子信息工程学院,山东青岛266400

出　　处：《中国医学影像技术》2024年第7期997-1002,共6页Chinese Journal of Medical Imaging Technology

摘　　要：目的观察终末期肾病(ESRD)患者脑网络动态功能连接改变。方法回顾性分析30例ESRD患者(ESRD组)与33名健康受试者(对照组),采用图论分析方法基于颅脑静息态功能MRI(rs-fMRI)对动态功能连接(dFC)参数进行组间比较,评估ESRD患者dFC与网络拓扑结构异常,并以Pearson相关性分析观察其与临床变量的相关性。结果相比对照组,ESRD组时间分数与平均驻留时间在状态二下升高、状态三下减低(P均<0.05),其异常功能连接主要见于默认模式网络、感觉运动网络、皮质下核、执行和注意网络、视觉网络、小脑网络内及网络间。ESRD组网络密度及双侧颞上回节点度均低于对照组(P均<0.05)。ESRD组状态二、三下的功能连接及图论属性异常参数与其临床指标均无明显相关(P均>0.05)。结论ESRD患者存在与认知功能损伤有关的脑动态网络时间属性及网络拓扑结构异常。Objective To investigate the temporal properties of dynamic functional connectivity of brain networks and the variability of network topology in patients with end-stage renal disease(ESRD).Methods Data of 30 ESRD patients(ESRD group)and 33 healthy subjects(control group)were retrospectively analyzed.Based on cranial resting-state functional MRI(rs-fMRI),dynamic functional connectivity(dFC)and graph theory analysis were employed,and the abnormalities in network topology and dFC in ESRD patients were assessed through comparison of groups.Pearson correlation analysis was used to observe the correlation between abnormal dFC indicators and clinical variables.Results Compared with control group,temporal scores and the mean residence time in ESRD group were significantly higher under stateⅡbut significantly lower under stateⅢ(both P<0.05).The abnormal functional connectivity in ESRD patients under statesⅡandⅢdistributed mainly within and between default mode network,sensorimotor network,subcortical nuclei,execution and attention network,visual network and cerebellum networks.Network density and bilateral superior temporal gyrus nodal degrees in ESRD group were all significantly lower than those in control group(all P<0.05).No significant correlation was found between the abnormal parameters of functional connectivity and graph theory attributes in ESRD group and clinical indicators under statesⅡnorⅢ(all P>0.05).Conclusion ESRD patients had abnormal temporal attributes and network topology of brain dynamic networks related to cognitive impairments.

关 键 词：肾衰竭 慢性 磁共振成像 功能连接 

分 类 号：R692[医药卫生—泌尿科学] R445[医药卫生—外科学]