^(68)Ga-FAPI PET显像用于心血管疾病研究进展  

Research progresses of ^(68)Ga-FAPI PET imaging in cardiovascular diseases

作　　者：林学智 张国建[2,3] LIN Xuezhi;ZHANG Guojian(The First Clinical Medical College of Inner Mongolia Medical University,Hohhot 010050,China;Department of Nuclear Medicine,the Affiliated Hospital of Inner Mongolia Medical University,Hohhot 010050,China;Key Laboratory of Molecular Imaging,Inner Mongolia Autonomous Region,Hohhot 010050,China)

机构地区：[1]内蒙古医科大学第一临床医学院,内蒙古呼和浩特010050 [2]内蒙古医科大学附属医院核医学科,内蒙古呼和浩特010050 [3]内蒙古自治区分子影像重点实验室,内蒙古呼和浩特010050

出　　处：《中国医学影像技术》2024年第7期1096-1099,共4页Chinese Journal of Medical Imaging Technology

基　　金：内蒙古科技成果转化专项(2019CG097)。

摘　　要：心肌纤维化与多种心血管疾病(CVD)发生、发展密切相关,而成纤维细胞激活蛋白(FAP)在其中发挥关键作用。^(68)Ga-FAP抑制剂(FAPI)对FAP具有高亲和力及特异度,现已逐渐用于心血管PET显像。本文围绕^(68)Ga-FAPI PET显像用于CVD研究进展进行综述。Myocardial fibrosis is closely related to the occurrence and development of various cardiovascular diseases(CVD),in which fibroblast activation protein(FAP)plays key roles.^(68)Ga-FAP inhibitors(FAPI)have high affinity and specificity for FAP,having been gradually applied to cardiovascular PET imaging.The research progresses of ^(68)Ga-FAPI PET imaging in cardiovascular diseases were reviewed in this article.

关 键 词：成纤维细胞激活蛋白α 心血管疾病 正电子发射断层显像 

分 类 号：R54[医药卫生—心血管疾病] R817.4[医药卫生—内科学]