Nanoparticle targeting cGAS-STING signaling in disease therapy  

作　　者：Lan Zhou Yu Huang Yuzhang Wu Shupei Tang 

机构地区：[1]Frontier Medical Training Brigade,Third Military Medical University,Hutubi 831200,China [2]Department of Gastroenterology,Xinqiao Hospital,Third Military Medical University,Chongqing 400037,China [3]Institute of Immunology,Third Military Medical University,Chongqing 400038,China [4]Shigatse Branch,Xinqiao Hospital,Third Military Medical University,Shigatse 857000,China

出　　处：《Nano Research》2024年第8期7315-7336,共22页纳米研究（英文版）

基　　金：supported by Natural Science Foundation of Shigatse City(No.RKZ2024ZR-002);the National Natural Science Foundation of China(No.32141005);Chongqing Science and Health Joint Medical Research Project(No.2020MSXM127).

摘　　要：The cyclic guanosine monophosphate-adenosine monophosphate synthase-stimulator of interferon(IFN)genes(cGAS-STING)signaling pathway is crucial for sensing abnormal DNA accumulation in the cytoplasm.Once binds to abnormal DNA,cGAS catalyzes the production of second messenger cyclic dinucleotides,followed by the activation of downstream STING.This activation induces the expression of type I interferon and other inflammatory cytokines,ultimately initiating an immune response.Due to the involvement of the cGAS-STING pathway in various diseases,including infection,tumor,autoimmune disease and kidney disease,ongoing research is focused on developing drugs and treatment methods to target and regulate this pathway.With the development of nanotechnology,nanomedicines targeting cGAS-STING signaling are of great significance in clinical applications due to their targeted delivery,controlled drug release,improved solubility,multifunctionality,and enhanced stability.This comprehensive review focuses on the most recent progress of nanoplatforms targeting cGAS-STING in disease therapy,aiming to provide references and guidelines for further design and optimization of nanomedicines.

关 键 词：NANOMEDICINE cGAS-STING pathway and related disease anti-tumor nanotherapy anti-viral nanotherapy 

分 类 号：TB383[一般工业技术—材料科学与工程]