Peroxidase-like active Cu-ZIF-8 with rich copper(I)-nitrogen sites for excellent antibacterial performances toward drug-resistant bacteria  

作　　者：Xiaoze Wang Hui Wang Jingkun Zhang Ning Han Wenjun Ma Donghai Zhang Mingshui Yao Xianliang Wang Yunfa Chen 

机构地区：[1]State Key Laboratory of Mesoscience and Engineering,Institute of Process Engineering,Chinese Academy of Sciences,Beijing 100190,China [2]University of the Chinese Academy of Sciences,Beijing 100049,China [3]Laboratory of Theoretical and Computational Nanoscience,CAS Key Laboratory of Nanosystem and Hierarchial Fabrication,CAS Center for Excellence in Nanoscience,National Center for Nanoscience and Technology,Beijing 100190,China [4]China CDC Key Laboratory of Environment and Population Health,National Institute of Environmental Health,Chinese Center for Disease Control and Prevention,Beijing 100021,China

出　　处：《Nano Research》2024年第8期7427-7435,共9页纳米研究（英文版）

基　　金：supported by the National Key R&D Program of China(No.2022YFC3702800);Beijing Natural Science Foundation(No.2232017);the research fund of State Key Laboratory of Mesoscience and Engineering(Nos.MESO-23-A07,and MESO-23-T02).

摘　　要：Bacterial pathogens pose a serious threat to human health,and there is an urgent need to develop highly effective antibacterial materials to eliminate the increasingly serious contamination of drug-resistant bacteria.Here,a Cu-doped ZIF-8 particle with unsaturated copper exhibits high peroxidase-like activity.99.998%antibacterial efficiency against S.aureus can be achieved for 30 min at a low concentration of 50μg·mL^(−1),as well as complete sterilization against E.coli(up to 8 log).99.999%antibacterial efficiency against Methicillin-resistant Staphylococcus aureus can be achieved,performing orders of magnitude higher than Vancomycin.The mechanism shows that the unsaturated Cu-Nx sites are enzyme-like active centers,which could promote the consumption of bacteria reducing substances by H_(2)O_(2),and the generated*OH further aggravates bacterial oxidative stress and membrane damage.More importantly,the oxidation activity of adsorbed oxygen species on Cu-ZIF-8 is enhanced by charge transfer and structural changes between the ligand and copper center like natural enzymes.Cu-doped ZIF-8 with peroxidase-like activity shows great potential in antibacterial application and the revealed catalytic mechanism is helpful for understanding the high antibacterial activity of nanoparticles with Cu-Nx sites.

关 键 词：Cu-doped ZIF-8 peroxidase-like reactive oxygen species(ROS) catalytic mechanism antibacterial activity 

分 类 号：O62[理学—有机化学]