A passive,reusable,and resonating wearable sensing system for ondemand,non-invasive,and wireless molecular stress biomarker detection  

作　　者：Shingirirai Chakoma Xiaochang Pei Huiting Qin Anita Ghandehari Sahar NajafiKhoshnoo Jerome Rajendran Rahim Esfandyarpour 

机构地区：[1]Department of Electrical Engineering and Computer Science,University of California,Irvine,CA 92697,USA [2]Laboratory for Integrated Nano BioElectronics Innovation,The Henry Samueli School of Engineering,University of California,Irvine,CA 92697,USA [3]Henry Samueli School of Engineering,University of California,Irvine,CA 92697,USA

出　　处：《Nano Research》2024年第8期7542-7556,共15页纳米研究（英文版）

基　　金：supported by the start-up funds provided to R.E.by the Henry Samueli School of Engineering and the Department of Electrical Engineering and Computer Science at the University of California,Irvine.

摘　　要：The significant impact of stress on health necessitates accurate assessment methods,where traditional questionnaires lack reliability and objectivity.Current advancements like wearables with electrocardiogram(ECG)and galvanic skin response(GSR)sensors face accuracy and artifact challenges.Molecular biosensors detecting cortisol,a critical stress hormone,present a promising solution.However,existing cortisol assays,requiring saliva,urine,or blood,are complex,expensive,and unsuitable for continuous monitoring.Our study introduces a passive,molecularly imprinted polymer-radio-frequency(MIP-RF)wearable sensing system for real-time,non-invasive sweat cortisol assessment.This system is wireless,flexible,battery-free,reusable,environmentally stable,and designed for long-term monitoring,using an inductance-capacitance transducer.The transducer translates cortisol concentrations into resonant frequency shifts with high sensitivity(~160 kHz/(log(μM)))across a physiological range of 0.025–1μM.Integrated with near-field communication(NFC)for wireless and battery-free operation,and threedimensional(3D)-printed microfluidic channel for in-situ sweat collection,it enables daily activity cortisol level tracking.Validation of cortisol circadian rhythm through morning and evening measurements demonstrates its effectiveness in tracking and monitoring sweat cortisol levels.A 28-day stability test and the use of cost-effective 3D nanomaterials printing enhance its economic viability and reusability.This innovation paves the way for a new era in realistic,on-demand health monitoring outside the laboratory,leveraging wearable technology for molecular stress biomarker detection.

关 键 词：CORTISOL WEARABLE flexible sensors three-dimensional(3D)nanomaterials printing REUSABLE environmentally stable 

分 类 号：TP212[自动化与计算机技术—检测技术与自动化装置]