Rapid synthesis of oxygen-defected molybdenum oxides quantum dots as efficient nanozymes for healing diabetic ulcers  

作　　者：Fangjun Cao Hui Feng Jiaxin Yao Xiang Hou Tiezhi Jin Junfeng Hui 

机构地区：[1]Shaanxi Key Laboratory of Qinling Ecological Security,Shaanxi Institute of Zoology,Xi’an 710072,China [2]Engineering Research Center of Western Resource Innovation Medicine Green Manufacturing,Ministry of Education,School of Chemical Engineering,Northwest University,Xi'an 710069,China [3]Shaanxi Key Laboratory of Degradable Biomedical Materials and Shaanxi R&D Center of Biomaterials and Fermentation Engineering,School of Chemical Engineering,Northwest University,Xi'an 710069,China

出　　处：《Nano Research》2024年第7期6376-6385,共10页纳米研究（英文版）

基　　金：supported by the National Natural Science Foundation of China(Nos.32172436 and 32000353);Key R&D Plan of Shaanxi Province(No.2020ZDLNY02-02);the Science and Technology Research Project of Shaanxi Province Academy of Sciences(No.2021k-38).

摘　　要：The continuous inflammatory response in diabetic skin wounds leads to excessive production of reactive oxygen species,which cause a vicious circle of long-term inflammation.In the therapeutic research of metal nanoenzymes for healing diabetic ulcers,it still faces the challenges in poor nanoenzymes activity and low-efficient therapeutic efficiency.Herein,ultrasmall oxygen-deficient MoO_(3−X)quantum dots were fabricated and employed as nanoenzymes for healing fiabetic ulcers.After PEGylation,PEGylated MoO_(3−X)quantum dots(MoO_(3−X)/PEG)with oxygen vacancies exhibits excellent photothermal,peroxidase/catalase-like activities.In addition,these MoO_(3−X)/PEG showed superior properties in scavenging H_(2)O_(2)and effectively inhibiting the scavenging of reactive oxygen species.More importantly,such an oxygen-defected MoO_(3−X)/PEG had obvious antibacterial and skin repairing effects on alleviating hypoxia and excessive oxidative stress even in a mouse model of diabetic ulcers,inhibiting proinflammatory cytokines and significantly accelerating the healing of infected wounds,which shows great application potential for promoting wound healing.This work highlights that the developed oxygen defected molybdenum oxide compounds capable of peroxidaselike and catalase-like activities show great application potential for healing diabetes wound.

关 键 词：oxygen-defected molybdenum-based nanoenzymes antioxidant ANTI-INFLAMMATORY diabetes ulcer wounds 

分 类 号：R587.1[医药卫生—内分泌]