Recent advances in molecular and nanoparticle probes for fluorescent bioanalysis  

作　　者：Haowen Luo Lejie Tian Yaoming Zhang Yang Wu Bin Li Jianxi Liu 

机构地区：[1]State Key Laboratory of Solidification Processing,Center of Advanced Lubrication and Seal Materials,School of Materials Science and Engineering,Northwestern Polytechnical University,Xi’an 710072,China [2]Yantai Zhongke Research Institute of Advanced Materials and Green Chemical Engineering,Shandong Laboratory of Advanced Materials and Green Manufacturing,Yantai 264006,China [3]State Key Laboratory of Solid Lubrication,Lanzhou Institute of Chemical Physics,Chinese Academy of Sciences,Lanzhou 730000,China

出　　处：《Nano Research》2024年第7期6443-6474,共32页纳米研究（英文版）

基　　金：the National Natural Science Foundation of China(No.52071270);the Science Fund of Shandong Laboratory of Advanced Materials and Green Manufacturing(Yantai)(No.AMGM2023F03);the Natural Science Foundation of Shaanxi Province(No.2024RS-CXTD-62);the Research Fund of the State Key Laboratory of Solidification Processing(NPU)(No.2022-QZ-04).

摘　　要：With the increasing emphasis on ecological safety and physical health,the detection and treatment of harmful substances and diseases are becoming more and more prevalent.Therefore,efficiently monitoring these biological behaviors with high accuracy and sensitivity in real-time has shown prominent research significance.The use of fluorescent probes to analyze organisms has gained momentum in recent years,especially in the field of organ imaging and assisted cancer therapy,where fluorescent bioanalysis demonstrates significant advantageous.In this review,we explored the latest advancements in fluorescent molecular probes(e.g.,small-molecule,macro-molecule,supramolecule)and fluorescent nanoparticle probes(e.g.,quantum dots or nanoclusters,metal-organic frameworks,polymers,complexes)used as bioanalytical tools in various assays over the last three years.We also delved into their detective mechanisms,specific application areas,and characterization tools for responsive behavior.This review aims to showcase the most recent and comprehensive research progress in fluorescent bioanalysis based on molecular and nanoparticle probes,offering guidance for future developments in the design and fabrication of fluorescent probes and their potential applications.

关 键 词：FLUORESCENT BIOSENSING BIOIMAGING disease diagnosis tumor detection and treatment 

分 类 号：TB383[一般工业技术—材料科学与工程]