67例新型冠状病毒感染舌象出现伤阴表现危险因素的病例对照研究  

The risk factors of 67 COVID-19 patients with tongue images ofY in-injury:A case-control study

作　　者：梁春耕 肖定洪 师金娟 刘曼曼 徐国海 周扬 LIANG Chungeng;XIAO Dinghong;SHI Jinjun;LIU Manman;XU Guohai;ZHOU Yang

机构地区：[1]上海市嘉定区中医医院,上海201899 [2]上海市嘉定区安亭医院,上海201800 [3]上海中医药大学附属岳阳中西医结合医院,上海200437

出　　处：《中医临床研究》2024年第12期47-51,共5页Clinical Journal Of Chinese Medicine

基　　金：上海市卫健委科研项目[ZY(2018-2020)-ZWB-1001-CPJS34];上海市卫健委科研项目[ZY(2021-2023)-0204-12]。

摘　　要：目的:研究新型冠状病毒感染患者舌象出现伤阴表现的危险因素。方法:采用单中心回顾性病例对照研究方法,纳入上海市嘉定区安亭医院2022年4―5月67名新型冠状病毒感染患者,以舌象出现伤阴表现为研究终点,分析与患者舌象出现伤阴表现相关的可能危险因素[性别、年龄、既往病史、疫苗接种、入院时检验结果(包括血常规、肝肾功能、电解质、D-二聚体、核酸CT值)]。结果:与舌象未出现伤阴表现者相比,单因素分析显示,舌象出现伤阴表现患者年龄显著升高,心脑血管疾病发生率明显升高,中性粒细胞比例显著升高,淋巴细胞百分比、嗜酸性粒细胞数、嗜酸性粒细胞百分比、D-二聚体、入院时血氧饱和度明显降低(P<0.05)。二元Logistics回归表明,年龄与舌象出现伤阴表现独立相关[95%CI 1.073(1.009,1.141)]。本研究中两例新型冠状病毒感染重症患者均为老年患者,且疾病发展过程中存在显著伤阴表现。结论:年龄是新型冠状病毒感染患者舌象出现伤阴表现的危险因素,同时合并心脑血管疾病、血中性粒细胞百分比升高,以及淋巴细胞百分比、嗜酸性粒细胞数、嗜酸性粒细胞百分比、D-二聚体升高有可能提示新型冠状病毒感染患者舌象出现伤阴表现风险升高,为养阴药物应用时机提供一定的指导意义。Objective:To study the risk factors of Yin-injury in tongue images of COVID-19 patients.Methods:A single-center retrospective case-control study was used to include 67 patients with COVID-19 from Anting Hospital,Jiading District,Shanghai,from April to May 2022,with tongue images showing Yin-injury as the study endpoint.The possible risk factors[gender,age,previous medical history,vaccination,test results on admission(including blood routine,liver and kidney function indexes,electrolytes,D-dimer,nucleic acid CT value)]related to the appearance of Yin-injury were analyzed.Results:Compared with those who did not show Yin-injury in the tongue images,univariate analysis showed that the age of the patients with Yin-injury in tongue images was significantly increased,the incidence of cardiovascular and cerebrovascular diseases was significantly increased,the proportion of neutrophils was significantly increased,and the percentage of lymphocytes,the number of eosinophils,the percentage of eosinophils,D-dimer and blood oxygen saturation were significantly decreased(P<0.05).Binary logistics regression showed that age was independently correlated with the expression of Yin-injury in tongue images[95%CI 1.073(1.009,1.141)].In this study,two severe patients with COVID-19 were elderly patients,both showed significant Yin-injury during the development of the disease.Conclusion:Age is a risk factor for Yin-injury in tongue images of COVID-19 patients.Meanwhile,the combination of increased percentage of neutrophil and lymphocyte,number of eosinophils,percentage of eosinophils and D-dimer may indicate an increased risk of Yin-injury in tongue images of COVID-19 patients.It provides some guiding significance for the application time of Yin-nourishing drugs.

关 键 词：新型冠状病毒感染 伤阴 年龄 舌象 

分 类 号：R254[医药卫生—中医内科学]