艾灸联合西药规范化治疗肺结核疗效观察及对外周血T淋巴细胞亚群变化的影响  

Observation on Curative Effect of Moxibustion Combined with Standardized Western Medicine on Pulmonary Tuberculosis and Its Effect on Changes of T Lymphocyte Subsets in Peripheral Blood

作　　者：廉桃梅 李坤营 白玺 陈瑛[1] 崔晓华[1] LIAN Taomei;LI Kunying;BAI Xi;CHEN Ying;CUI Xiaohua(First ward of Tuberculosis Department of Internal Medicine,Henan Provincial Chest Hospital,Zhengzhou Henan 450000,China;Endoscopic Center,Henan Provincial Chest Hospital,Zhengzhou Henan 450000,China)

机构地区：[1]河南省胸科医院结核内科一病区,河南郑州450000 [2]河南省胸科医院内镜中心,河南郑州450000

出　　处：《新中医》2024年第12期147-151,共5页New Chinese Medicine

摘　　要：目的:观察艾灸联合西药规范化治疗肺结核(PTB)的临床疗效及对外周血T淋巴细胞亚群变化的影响。方法:选择104例PTB患者作为研究对象,按随机数字表法分为观察组与对照组各52例。对照组给予西药规范化治疗(2HRZS/4HR标准化疗方案),观察组在对照组基础上联合艾灸辅助治疗。治疗6个月,比较2组临床疗效、病灶吸收率、痰菌转阴率、中医证候评分及外周血T淋巴细胞亚群(CD3^(+)、CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+))水平变化。结果:观察组总有效率为94.23%,对照组为76.92%,2组比较,差异有统计学意义(P<0.05)。观察组病灶吸收有效率为90.38%,对照组为73.08%,2组比较,差异有统计学意义(P<0.05)。观察组痰菌转阴率为82.69%,对照组为61.54%,2组比较,差异有统计学意义(P<0.05)。治疗后,2组中医证候评分均较治疗前降低(P<0.05),且观察组中医证候评分低于对照组(P<0.05)。治疗后,2组CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)水平均较治疗前升高(P<0.05),且观察组CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)水平均高于对照组(P<0.05);2组CD8^(+)水平均较治疗前降低(P<0.05),且观察组CD8^(+)水平低于对照组(P<0.05)。结论:艾灸辅助2HRZE/4HR方案规范化治疗PTB疗效确切,可明显促进病灶吸收及痰菌转阴,有效改善其临床症状和免疫功能。Objective:To observe the clinical effect of moxibustion combined with standardized western medicine on pulmonary tuberculosis(PTB)and its effect on changes of T lymphocyte subsets in peripheral blood.Methods:A total of 104 cases of patients with PTB were selected as the study objects and divided into the observation group and the control group according to the random number table method,with 52 cases in each group.The control group was treated with standardized western medicine(2HRZS/4HR standard chemotherapy regimen),and the observation group was additionally treated with moxibustion based on the treatment of the control group.After six months of treatment,clinical effects,lesion absorption rates,sputum negative conversion rates,traditional Chinese medicine(TCM)syndrome scores and changes in the levels of T lymphocyte subsets(CD3^(+),CD4^(+),CD8^(+),CD4^(+)/CD8^(+))in peripheral blood were compared between the two groups.Results:The total effective rate was 94.23%in the observation group and 76.92%in the control group,the difference being significant(P<0.05).The effective rate of lesion absorption was 90.38%in the observation group and 73.08%in the control group,the difference being significant(P<0.05).The sputum negative conversion rate was 82.69%in the observation group and 61.54%in the control group,the difference being significant(P<0.05).After treatment,TCM syndrome scores in the two groups were decreased when compared with those before treatment(P<0.05),and the TCM syndrome score in the observation group was lower than that in the control group(P<0.05).After treatment,the levels of CD3^(+),CD4^(+)and CD4^(+)/CD8^(+)in the two groups were increased when compared with those before treatment(P<0.05),and the levels of CD3^(+),CD4^(+)and CD4^(+)/CD8^(+)in the observation group were higher than those in the control group(P<0.05);CD8^(+)levels in the two groups were decreased when compared with those before treatment(P<0.05),and the level in the observation group was lower than that in the control group(P<0.05).C

关 键 词：肺结核 艾灸 2HRZE/4HR方案 病灶吸收率 痰菌转阴率 T淋巴细胞亚群 

分 类 号：R521[医药卫生—内科学]