左心室射血分数和空腹血糖水平与冠状动脉疾病患者经皮冠状动脉介入术后主要不良心血管和脑血管事件的相关性  

Correlation between left ventricular ejection fraction and fasting plasma glucose levels with major adverse cardiovascular and cerebrovascular events in patients with coronary artery disease after percutaneous coronary intervention

作　　者：朱昌国 孟昭昀 Zhu Changguo;Meng Zhaoyun(Department of General Medicine,Jinan City People's Hospital,Jinan 271100,China)

机构地区：[1]山东省济南市人民医院全科医学科,271100

出　　处：《心脑血管病防治》2024年第6期4-7,12,共5页CARDIO-CEREBROVASCULAR DISEASE PREVENTION AND TREATMENT

摘　　要：目的探讨左心室射血分数和空腹血糖水平与冠状动脉疾病(CAD)患者经皮冠状动脉介入(PCI)术后主要不良心血管和脑血管事件(MACCE)的相关性。方法从Dryad数据库中提取巴西圣保罗大学医学院心脏研究所单中心回顾性研究数据。该研究共纳入接受PCI治疗的CAD患者573例,根据随访5年内是否发生MACCE将患者分为MACCE组164例和对照组409例。比较两组患者的年龄、性别、左心室射血分数、空腹血糖水平等临床资料,使用多因素Cox回归分析,评估左心室射血分数和空腹血糖水平对CAD患者PCI术后MACCE发生的预测价值,Kaplan-Meier法评价不同左心室射血分数和血糖水平患者生存率的差异。结果左心室射血分数50%~70%、左心室射血分数>70%是CAD患者PCI后MACCE发生的保护因素[HR(95%CI)=0.578(0.367~0.914)、0.493(0.279~0.858),P<0.05];空腹血糖≥6.1 mmol/L是CAD患者PCI后MACCE发生的危险因素[HR(95%CI)=1.492(1.026~2.138),P<0.05]。左心室射血分数<50%患者生存率低于左心室射血分数50%~70%和左心室射血分数>70%患者(χ^(2)=5.530、7.450,P<0.05)。空腹血糖<6.1 mmol/L患者生存率高于空腹血糖≥6.1 mmol/L患者(χ^(2)=12.212,P<0.05)。结论左心室射血分数和空腹血糖均是CAD患者PCI后MACCE发生的影响因素。Objective To explore the correlation between left ventricular ejection fraction(LVEF)and fasting plasma glucose(FPG)levels with the occurrence of major adverse cardiovascular and cerebrovascular events(MACCE)in patients with coronary artery disease(CAD)after percutaneous coronary intervention(PCI).Methods Data were extracted from the Dryad database of singlecenter retrospective study conducted at the Heart Institute,Faculdade de Medicina da Universidade de São Paulo,Brazil.A total of 573 CAD patients underwent PCI were included in this study.Based on the occurrence of MACCE during the follow-up period of 5 years,patients were divided into the MACCE group(164 cases)and the control group(409 cases).Clinical data including age,gender,LVEF,and FPG levels were compared between the two groups.Multivariate Cox regression analysis was used to evaluate the predictive value of LVEF and FPG levels in the occurrence of MACCE after PCI in patients with CAD.Kaplan-Meier method was used to evaluate survival differences among patients with different LVEF and FPG levels.Results LVEF of 50%-70% and LVEF>70% were protective factors for MACCE occurrence after PCI in CAD patients[HR(95%CI)=0.578(0.367-0.914),0.493(0.279-0.858);P<0.05].FPG≥6.1 mmol/L was a risk factor for the occurrence of MACCE after PCI in patients with CAD[HR(95%CI)=1.492(1.026-2.138),P<0.05].The survival rate of patients with LVEF<50% was lower than that of patients with LVEF of 50%-70% and LVEF>70%(χ^(2)=5.530,7.450;P<0.05).The survival rate of patients with FPG<6.1 mmol/L was higher than that of patients with FPG≥6.1mmol/L(χ^(2)=12.212,P<0.05).Conclusion LVEF and FPG levels are influencing factors for the occurrence of MACCE in CAD patients after PCI.

关 键 词：左心室射血分数 空腹血糖 冠状动脉疾病 经皮冠状动脉介入 主要不良心血管和脑血管事件 

分 类 号：R541.4[医药卫生—心血管疾病]