纳米氧化石墨烯作为临床药物载体在肿瘤治疗中的研究  

Development of nanographene oxide as clinical drug carrier in cancer therapy

作　　者：钟春莲 方昌建 周桂羽 朱慧玲 郑镗 庄婉晶 刘剑 卢余盛 ZHONG Chun-lian;FANG Chang-jian;ZHOU Gui-yu;ZHU Hui-ling;ZHENG Tang;ZHUANG Wan-jing;LIU Jian;LU Yu-sheng(College of Materials and Chemical Engineering,Minjiang University,Fujian-Taiwan-Hongkong-Macao Science and Technology Cooperation Base of Intelligent Pharmaceutics;Fuzhou Institute of Oceanography,Minjiang University,Fuzhou 350108,China;School of Life Sciences,Xiamen University,State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics,National Institute of Diagnostics and Vaccine Development in Infectious Diseases,Xiamen,Fujian 361102,China;College of Pharmacy,Fujian University of Traditional Chinese Medicine,Institute of Structural Pharmacology&TCM Chemical Biology,Fuzhou 350122,China)

机构地区：[1]闽江学院材料与化学工程学院,福建省智能药物闽台港澳科技合作基地 [2]闽江学院福州海洋研究院,海洋药物研发中心,福建福州350108 [3]厦门大学生命科学学院,分子病毒学与分子诊断学国家重点实验室,国家传染病诊断试剂与疫苗工程技术研究中心,福建厦门361102 [4]福建中医药大学药学院,结构药理学与中药化学生物学研究所,福建福州350122

出　　处：《中国药理学通报》2024年第8期1413-1418,共6页Chinese Pharmacological Bulletin

基　　金：国家自然科学基金资助项目(No.82104406);福建省级大学生创新创业训练计划(No.S202210395056)。

摘　　要：免疫治疗的出现开创了癌症治疗的新时代,但其临床疗效有限,其中一个主要原因是肿瘤局部药物浓度过低,不能有效激活机体的免疫反应。纳米材料因其独特的载药优势,逐渐应用于临床肿瘤治疗。纳米氧化石墨烯(nanographene oxide,NGO)是一种新型二维纳米材料,具有巨大的载药界面,化学稳定性、生物相容性及高效的光热转换效率等。此外,功能化修饰可实现药物的靶向输送,减少药物的毒副作用,提高药物在肿瘤部位的富集浓度。该文概述了NGO在肿瘤药物装载、靶向输送及肿瘤光热治疗等方面的应用与挑战,有望为今后纳米氧化石墨烯应用于临床肿瘤治疗提供理论基础。Immunotherapy is an important breakthrough in cancer treatment.Unfortunately,low drug concentration in tumor sites almost ineffectively initiates immune responses and thereby severely limits immune therapy applications in clinics.Nanomaterials are well-recognized drug delivery system in cancer therapy.Nanographene oxide(NGO)have shown immense pertinence for anti-cancer drug delivery owing to their ultra-high surface area,chemical stability,good biocompatibility and excellent photosensitivity.In addition,functionalized modifications on the surface of NGO increase tumor targeting and minimize cytotoxicity.This study focuses on reviewing the literature and updates on NGO in drug delivery and discussing the possibilities and challenges of NGO in cancer synergetic therapy.

关 键 词：癌症治疗 纳米氧化石墨烯 药物装载 靶向输送 光热治疗 联合治疗 

分 类 号：R318[医药卫生—生物医学工程] R730.5[医药卫生—基础医学] R944.9