多巴胺奖赏系统参与抑郁环路机制及中医药干预研究思考与展望  

Reflection and prospect on mechanism of dopamine reward system involvement in depression loop and traditional Chinese medicine intervention research

作　　者：李卓娴 周流畅 叶丽宏 邓迪[3] 赵金兰 史亚飞[1] 张荣 LI Zhuo-xian;ZHOU Liu-chang;YE Li-hong;DENG Di;ZHAO Jin-lan;SHI Ya-fei;ZHANG Rong(School of Basic Medicine,Guangzhou University of Traditional Chinese Medicine,Guangzhou 510006,China;Second Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine,Guangdong Provincial Key Laboratory of Clincal Reserach on Traditional Chinese Medicine Syndrome,Guangzhou 510120,China;School of Traditional Chinese Medicine/International Institute of Translational Medicine,Guangzhou 510006,China)

机构地区：[1]广州中医药大学基础医学院,广东广州510006 [2]广州中医药大学第二附属医院,广东省中医证候临床研究重点实验室,广东广州510120 [3]广州中医药大学中药学院/国际转化医学研究所,广东广州510006

出　　处：《中国药理学通报》2024年第8期1424-1429,共6页Chinese Pharmacological Bulletin

基　　金：国家自然科学基金资助项目(No.82074219,82274226,82274443,82104557,82104623);广东省基础与应用基础研究基金(No.2021A1515012572,2022A1515010230);广州市科技计划(No.202201011267);广州中医药大学学科协同创新团队重点项目(No.2021xk29);广东省科技计划项目(No.2023B1212060063)。

摘　　要：在寻找提升抗抑郁疗效新策略的过程中,中医药干预逐渐展露出其独特的防治优势。多巴胺奖赏系统密切参与了抑郁症的病理发生发展过程,现今研究多聚焦于多巴胺奖赏系统中某一特定核团的功能机制,而着眼于神经环路功能机制所开展的研究较少。当前奖赏环路的微观研究中,奖赏环路异常和焦虑、抑郁等负面情绪的关联性已获得广泛认可,中医药干预可通过影响奖赏环路发挥抗抑郁作用。该文围绕多巴胺奖赏系统参与抑郁症的环路机制以及中医药干预研究做一综述。In the process of seeking new strategies to improve the efficacy of antidepressants,traditional Chinese medicine intervention has gradually revealed its unique prevention and treatment advantages.The dopamine reward system is closely involved in the pathological occurrence and development of depression.Currently,research has mostly focused on the functional mechanism of a specific nucleus in the dopamine reward system,and there is less research focused on the functional mechanism of the neural circuit.In the current micro research on reward circuits,the association between abnormal reward circuits and negative emotions such as anxiety and depression has been widely recognized.Traditional Chinese medicine intervention can exert antidepressant effects by influencing reward circuits.This article provides a review on the loop mechanism of dopamine reward system involvement in depression and research on traditional Chinese medicine intervention.

关 键 词：抑郁症 奖赏系统 神经环路 多巴胺 腹侧背盖区 伏隔核 

分 类 号：R28[医药卫生—中药学] R322.8[医药卫生—中医学] R749.42R971.9