二取代吡咯衍生物的合成与强碱性试剂DBU的促进作用研究  

Synthesis of Disubstituted Pyrrole Derivatives and Promotion of Strong Alkaline Reagent DBU

作　　者：何然 王永辉[1] HE Ran;WANG Yonghui(Chuzhou City Career Aademy,Chuzhou Anhui 239000,China)

机构地区：[1]滁州城市职业学院,安徽滁州239000

出　　处：《佳木斯大学学报（自然科学版）》2024年第7期160-163,共4页Journal of Jiamusi University：Natural Science Edition

基　　金：滁州城市职业学院教学研究重点项目(2022zdjyxm06);滁州城市职业学院科研重点项目(2023zkzd02)。

摘　　要：提出了一种使用强碱性试剂1,8-二氮杂二环十一碳-7-烯,促进二取代衍生物的合成,实现提高二取代衍生物制备效率的目的。利用该方法进行实验,结果表明,未使用强碱性试剂的2,4-二取代吡咯化合物的产率为20%,使用强碱性试剂后2,4-二取代吡咯化合物的产率由20%上升到55%,且随着DBU试剂使用量的增加而增加,最终产率稳定在85%。综上,研究提出的使用强碱性试剂促进二取代吡咯衍生物合成的方法具有简单易行、高效且可控性好的特点,为进一步探索其在医药和材料科学领域的应用奠定基础。A strong basic reagent 1,8-diazadicycloundecane 7-ene was used to promote the synthesis of dissubstituted derivatives and improve the preparation efficiency of dissubstituted deriva-tives.The experimental results show that the yield of 2,4-dissubstituted pyrrole compound without u-sing strong basic reagent is 20%,and the yieldof 2,4-dissubstituted pyrrole com pound increases from 20%to 55%after using strong basic reagent,and increases with the increase of the use of DBU reagent,and the final yield is stable at 85%。In summary,the proposed method of promoting the synthesis of dissubstituted pyrrole derivatives with strong alkaline reagents is simple,efficient and controllable,which lays a foundation for further exploration of its application in medicine and materials science.

关 键 词：吡咯 二取代吡咯衍生物 DBU Hantzsch反应 

分 类 号：O626.13[理学—有机化学]