Displacement-pressure biparametrically regulated softness sensory system for intraocular pressure monitoring  

作　　者：Yu Cheng Yifei Zhan Fangyi Guan Junli Shi Jingxiao Wang Yi Sun Muhammad Zubair Cunjiang Yu Chuan Fei Guo 

机构地区：[1]Department of Materials Science and Engineering,Southern University of Science and Technology,Shenzhen 518055,China [2]Department of Engineering Science and Mechanics,Pennsylvania State University,State College 16802,USA [3]Department of Biomedical Engineering,Pennsylvania State University,State College 16802,USA [4]Department of Materials Science and Engineering,Materials Research Institute,Pennsylvania State University,State College 16802,USA

出　　处：《National Science Review》2024年第6期152-161,共10页国家科学评论（英文版）

基　　金：funded by the National Natural Science Foundation of China(T2225017 and 52073138);the Science Technology and Innovation Committee of Shenzhen Municipality(JCYJ20210324120202007);the Shenzhen Sci-Tech Fund(YTDPT20181011104007);the Guangdong Provincial Key LaboratoryProgram(2021B1212040001).

摘　　要：High intraocular pressure (IOP) is one of the high-risk pathogenic factors of glaucoma. Existing methods ofIOP measurement are based on the direct interaction with the cornea. Commercial ophthalmic tonometersbased on snapshot measurements are expensive, bulky, and their operation requires trained personnel.Theranostic contact lenses are easy to use, but they may block vision and cause infection. Here, we report asensory system for IOP assessment that uses a soft indentor with two asymmetrically deployed iontronicflexible pressure sensors to interact with the eyelid-eyeball in an eye-closed situation. Inspired by humanfingertip assessment of softness, the sensory system extracts displacement-pressure information for softevaluation, achieving high accuracy IOP monitoring (>96%). We further design and custom-make aportable and wearable ophthalmic tonometer based on the sensory system and demonstrate its high efficacyin IOP screening. This sensory system paves a way towards cost-effective, robust, and reliable IOPmonitoring.

关 键 词：intraocular pressure TONOMETER deep learning SOFTNESS iontronic sensor 

分 类 号：TH776.1[机械工程—仪器科学与技术]