震颤蛋白-RNA相互作用在心血管疾病中的作用  

Roles of quaking-RNA interations in cardiovascular diseases

作　　者：卜佳乐 汤子君 谢宜欣 李珂娟 李勇男[1,4] 张小卫[1,2] BU Jiale;TANG Zijun;XIE Yixin;LI Kejuan;LI Yongnan;ZHANG Xiaowei(Lanzhou University Second Clinical Medical School,Lanzhou 730000,China;Department of Cardiovascular Medicine,The Second Hospital of Lanzhou University,Lanzhou 730000,China;Department of Hematology,The Second Hospital of Lanzhou University,Lanzhou 730000,China;Department of Cardiac Surgery,The Second Hospital of Lanzhou University,Lanzhou 730000,China)

机构地区：[1]兰州大学第二临床医学院,兰州730000 [2]兰州大学第二医院心血管内科,兰州730000 [3]兰州大学第二医院血液科,兰州730000 [4]兰州大学第二医院心外科,兰州730000

出　　处：《生命的化学》2024年第6期1047-1054,共8页Chemistry of Life

基　　金：国家自然科学基金地区科学基金项目(82060080);甘肃省科技厅项目(21JR11RA116,23YFFA0038);兰州大学第二医院萃英科技创新项目(CY2022-MS-A06,CY2022-QN-A17);甘肃省心脏康复工程研究中心项目(CRQI-C00535);兰州大学“创新之星”计划项目(2023CXZX-164);兰州大学医学研究生培养创新发展项目(lzuyxc-2022-128)。

摘　　要：RNA结合蛋白-震颤蛋白(quaking,QKI)是信号转导和激活RNA蛋白家族的成员,属于异质核糖核蛋白K同源结构域蛋白家族。QKI通过与RNA相互作用进而影响细胞分化、细胞增殖、细胞凋亡和细胞衰老等多种细胞生物学过程,可通过与RNA相互作用参与多种心血管疾病的发生发展。然而,目前缺乏对QKI/RNA作用机制在心血管疾病中研究进展的系统性总结。本文通过描述QKI的结构特征,阐述QKI与RNA相互调节影响的细胞生物学活动,总结QKI与RNA相互作用在心血管疾病中的潜在影响,旨在为心血管疾病提供新的诊疗靶点和理论依据。RNA binding protein quaking(QKI)is a member of the signal transduction and activation RNA family,which also belongs to the heterogeneous ribonucleoprotein K homeodomain protein family.QKI influences various cellular biological processes such as cell differentiation,cell proliferation,apoptosis,and cell aging through interaction with RNA.Numerous studies indicate that QKI can participate in the development of various cardiovascular diseases through its interaction with RNA.However,there is currently a lack of a systematic summary of research progress on the QKI/RNA interaction mechanism in cardiovascular diseases.This paper describes the structural characteristics of QKI and discusses the cellular biological activities regulated by the interaction between QKI and RNA,summarizing the potential impact of QKI-RNA interactions in cardiovascular diseases,aiming to provide new diagnostic and therapeutic targets and theoretical basis for cardiovascular diseases.

关 键 词：震颤蛋白 信使RNA 微小RNA 环状RNA 心血管疾病 

分 类 号：R54[医药卫生—心血管疾病]