血清肌钙蛋白I、肌红蛋白及肌酸激酶同工酶联合检测在急性心肌梗死早期诊断中的临床价值  

Value of Serum Troponin,Myoglobin and Creatine Kinase Isoenzyme Combined Detection in Early Diagnosis of Acute Myocardial Infarction

作　　者：郭海燕 郑昌琦 GUO Hai-yan;ZHENG Chang-qi(Department of Clinical Laboratory,Changyuan Hospital of Integrated Traditional Chinese and Western Medicine,Xinxiang 453400,China)

机构地区：[1]长垣中西医结合医院检验科,新乡453400

出　　处：《四川解剖学杂志》2024年第2期58-61,共4页Sichuan Journal of Anatomy

摘　　要：目的:探讨急性心肌梗死(AMI)早期诊断中,血清肌钙蛋白I(cTnI)、肌红蛋白(Mb)及肌酸激酶同工酶MB(CK-MB)联合检测的临床应用价值.方法:选取2021年7月至2023年7月本院收治的113例急性冠脉综合征患者为研究对象.以冠脉造影结果为依据,将62例AMI患者纳入AMI组;51例不稳定型心绞痛患者纳入对照组.依据Killip心功能分级,将62例AMI组患者分为Ⅰ级组(n=14)、Ⅱ级组(n=16)、Ⅲ级组(n=20)和Ⅳ级组(n=12);参照临床结局,将62例AMI组患者分为预后不良组(n=12,发生心血管不良事件或死亡患者)与预后良好组(n=50,未发生心血管不良事件患者).检测并比较各组受试者血清cTnI、CK-MB及Mb水平,联合冠脉造影结果进行比较,分析各项血清学指标对AMI的诊断价值.结果:AMI组cTnI、Mb及CK-MB水平均高于对照组,差异均有统计学意义(P<0.05);Ⅳ级组AMI患者的cTnI、Mb及CK-MB水平,均高于Ⅰ级组、Ⅱ级组及Ⅲ级组,差异均有统计学意义(P<0.05);预后不良组AMI患者cTnI、Mb及CK-MB水平,均高于预后良好组,差异均有统计学意义(P<0.05).联合检测对AMI诊断准确度高于Mb、CK-MB单一检测,诊断灵敏度高于cTnI、Mb、CK-MB单一检测,差异均有统计学意义(P<0.05).结论:血清cTnI、Mb及CK-MB联合检测,对AMI患者早期诊断具有一定临床应用价值.Objective:To explore clinical value of serum cardiac troponin I(cTnI),myoglobin(MB)and creatine kinase isoenzyme-MB(CK-MB)combined detection in early diagnosis of acute myocardial infarction(AMI).Methods:A total of 113 patients with acute coronary syndrome admitted to our hospital from July 2021 to July 2023 were selected as study subjects.According to the results of coronary angiography,62 AMI patients were assigned to AMI group and 51 unstable angina pectoris patients were assigned to control group.According to Killip cardiac function grade,AMI group(n=62)patients were divided into gradeⅠgroup(n=14),gradeⅡgroup(n=16),gradeⅢgroup(n=20)and gradeⅣgroup(n=12).According to clinical outcome,62 AMI patients were divided into the poor prognosis group(n=12,who had adverse cardiovascular events or death)and the good prognosis group(n=50,who had no adverse cardiovascular events).The serum cTnI,CK-MB and Mb levels were measured,the diagnostic value of each index and combined detection on AMI was analyzed.Results:The levels of cTnI,Mb and CK-MB in AMI group were higher than those in control group(P<0.05).The levels of cTnI,Mb and CK-MB in groupⅣwere higher than those in groupⅠ,groupⅡand groupⅢ(P<0.05).The levels of cTnI,Mb and CK-MB in the poor prognosis group were higher than those in the good prognosis group(P<0.05).The diagnostic accuracy of combined detection was higher than that of Mb and CK-MB single detection,and the diagnostic sensitivity was higher than that of cTnI,Mb and CK-MB single detection(P<0.05).Conclusion:The combined detection of serum cTnI,Mb and CK-MB in the early diagnosis of AMI has certain application value.

关 键 词：急性心肌梗死 肌钙蛋白I 肌酸激酶同工酶 肌红蛋白 诊断价值 

分 类 号：R542.22[医药卫生—心血管疾病]