针药结合效应刍议  

Discussion on the effects of acupuncture-medication combination

作　　者：陈红秀 于波 周影 李旭 李铁[1] CHEN Hongxiu;YU Bo;ZHOU Ying;LI Xu;LI Tie(School of Acupuncture-Moxibustion and Tuina,Changchun University of CM,Changchun 130117,Jilin Province,China;Institute of Microelectronics of the Chinese Academy of Sciences)

机构地区：[1]长春中医药大学针灸推拿学院,吉林长春130117 [2]中国科学院微电子研究所

出　　处：《中国针灸》2024年第7期838-844,共7页Chinese Acupuncture & Moxibustion

基　　金：国家重点研发计划项目:2022YFC3500402;国家自然科学基金面上项目:82274661。

摘　　要：总结和探讨针灸与药物在治疗过程中的联合作用结果,将针药结合效应概括为“针增药效、药增针效、针药协同、针药拮抗”4个方面。“针增药效”侧重针灸对药物的影响,包括针灸能够影响药物在体内的吸收和代谢过程,增加血药浓度;增强药物的靶向效应,引药归经;减少药物使用剂量及不良反应;避免首过效应,增加药物生物利用度。“药增针效”不仅体现药物对针灸的增效作用,还有药物本身对针灸器具的预处理以附加针具药物性能,进而提高疗效。“针药协同”和“针药拮抗”从不同侧面探讨了针灸与药物同时作用机体的可能效应,其作用靶点可能相同或不同,作用机制有待进一步深入探索。This article summarizes and discusses the collaborative effects of acupuncture and medication in treatment,including four aspects,named"acupuncture synergizing the effects of medication","medication advancing the effects of acupuncture","coordination of acupuncture and medication",and"antagonism of acupuncture and medication".Regarding"acupuncture synergizing the effects of medication",the actions of acupuncture are predominant,which affects the absorption and metabolism of drugs in the body,increases drug concentration in blood,enhances the targeting effect of drugs,guides meridian tropism,alleviates the drug dose and adverse reactions,avoids the first pass effect and accelerates the drug bioavailability.As for"medication advancing the effects of acupuncture",the synergistic effect of acupuncture is obtained by medication,besides,the medication itself may supplement the drug property to the needles during acupuncture pretreatment so as to increase the therapeutic effect.In terms of"coordination of acupuncture and medication",and"antagonism of acupuncture and medication",there are the underlying co-effects of acupuncture and medication in the body,and the action targets may be same or different between them,thus,it needs to be further explored.

关 键 词：针药结合 增效 减毒 拮抗 理论探讨 

分 类 号：R246[医药卫生—针灸推拿学]