胆汁酸驱动消化道炎癌转化及中医药防治策略  

Bile Acids Driving Digestive Tract Inflammation and Cancer Transformation and Traditional Chinese Medicine Prevention and Treatment Trategy

作　　者：刘宇婧 徐汉辰[1] 季光[1] Yujing Liu;Hanchen Xu;Guang Ji(Institute of Digestive Diseases/Longhua Hospital,Shanghai University of Traditional Chinese Medicine,Shanghai 201203)

机构地区：[1]上海中医药大学脾胃病研究所/附属龙华医院,上海201203

出　　处：《中国科学基金》2024年第3期461-468,共8页Bulletin of National Natural Science Foundation of China

基　　金：国家自然科学基金项目(82320108022,82322076)的资助。

摘　　要：消化道肿瘤在全球肿瘤发病和死亡排行榜上多年位居前列,更是我国高发肿瘤,极大的威胁着人民的生命健康。常见消化道肿瘤包括肝癌、胃癌、结直肠癌、食管癌等,均为典型的炎症依赖性肿瘤,其发生过程伴随着炎症微环境的浸润及炎—癌演变过程。因此,探究炎癌转化的驱动因素及寻找能有效靶向炎症向癌症转化关键节点的干预策略,从而控制消化道肿瘤的发生是关键科学问题。作为机体重要代谢物之一的胆汁酸,除了能发挥其正常生理功能外,还能在消化道炎癌转化进程中发挥重要作用。调节胆汁酸代谢是消化道炎癌转化防治的关键环节,同时以中医肝脾理论以及肠肝轴学说为理论依据,探讨通过胆汁途径抑制消化道炎症转化的防治策略。本文就胆汁酸驱动消化道炎癌转化的具体机制以及中医药防治策略进行相关论述,并进行了分析与展望。Gastrointestinal cancer has been in the forefront of cancer incidence and mortality in the world for many years,especially in China,which is a great threat to people's life and health.Common gastrointestinal cancers,including liver cancer,gastric cancer,colorectal cancer,esophageal cancer,etc.,are typical inflammation-dependent tumors,and their occurrence is accompanied by the infiltration of inflammatory microenvironment and the evolution of inflammatory cancer transformation Therefore,it is a key scientific issue to explore the driving factors of inflammatory cancer transformation and find effective intervention strategies to target the key nodes of inflammatory cancer transformation,thereby controlling the occurrence of gastrointestinal cancer.As one of the important metabolites of the body,bile acids not only play a normal physiological function,but also play an important role in the process of gastrointestinal inflammatory cancer transformation.The regulation of bile acid metabolism is the key to the prevention and treatment of digestive tract inflammation and cancer transformation.At the same time,based on the theory of liver and spleen of Traditional Chinese Medicine(TCM)and the theory of entero-liver axis,the prevention and treatment strategy of inhibiting digestive tract inflammation transformation through bile pathway was discussed.In this paper,the specific mechanism of bile acid-driven gastrointestinal inflammatory cancer transformation and the prevention and treatment strategies of TCM are discussed,analyzed and prospected.

关 键 词：消化道肿瘤 炎癌转化 胆汁酸 肝脾理论 肠肝循环 

分 类 号：R273[医药卫生—中西医结合]