通过神经—内分泌—免疫—代谢网络互作维持的自愈体系理解中医药学原理  

Understanding the Theory of Visceral Manifestation in Traditional Chinese Medicine Through the Self-healing System Maintained by The Neuro-Endocrine-Immune-Metabolic Networks

作　　者：刘欣安 贾艺聪 王立平[1,2,3] Xin-an Liu;Yicong Jia;Liping Wang(CAS Key Laboratory of Brain Connectome and Manipulation,Brain Cognition and Brain Disease Institute(BCBDI),Shenzhen Institute of Advanced Technology,Chinese Academy of Sciences,Shenzhen 518055;Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions,Shenzhen 518055;University of Chinese Academy of Sciences,Beijing 100190)

机构地区：[1]中国科学院脑联结解析与调控重点实验室/脑认知与脑疾病研究所/深圳先进技术研究院,深圳518055 [2]深港脑科学研究院,深圳518055 [3]中国科学院大学,北京100190

出　　处：《中国科学基金》2024年第3期492-500,共9页Bulletin of National Natural Science Foundation of China

基　　金：国家自然科学基金重点项目(32230042LW)、面上项目(32371213XL);广东省基础与应用基础研究基金(2022A1515110624YJ)的资助。

摘　　要：中医药现代化是新时代生命科学的分支内容,也是全球前沿科学的重要方向之一。中医观点中“正气存内,邪不可干”,是指人体正气足,外邪就无法入侵导致疾病。中医的“正气”指的是机体免疫力,是机体自愈力的来源。现代前沿科学认为,机体通过神经—内分泌—免疫—代谢网络的调控维持机体稳态平衡和健康;与之相统一的传统中医药理论藏象学说则认为,人体各脏腑相互联系,五脏化生,共同调动正气,正气盛则人体自愈力强。通过揭示机体稳态的网络调控机制有助于我们更好地理解中医药的整体观与精准干预,以及通过多靶点﹑多脏器的干预来发挥药物对疾病的治疗作用。运用前沿神经科学的思路及技术解读中医药学原理,以整体观与系统论为启发,以中医药临床与系统生物学等学科兼容并蓄,建立新的基础与临床研究框架,将推动还原论主导的现代医学体系与系统论启发的传统中医有效融合,推动藏象学说和自愈体系的调控理论在医学中运用。The modernisation of Traditional Chinese Medicine(TCM)is a branch of life sciences in the new era and one of the important directions of global frontier science.In TCM,the saying‘when there is positive energy in the body,evil cannot enter'means that if the body's positive energy is sufficient,external evils will not be able to enter the body and cause disease.The'positive energy'in TCM refers to the body's immunity,which is the source of the body's self-healing power.Modern cutting-edge science supposes that the organism maintains homeostatic balance and health through the regulation of the neuro-endocrine-immune-metabolic network;in line with this,the theory of visceral manifestation in TCM believes that the internal organs of the human body are interconnected,the five viscera mobilise positive energy,and the human body is strong in self-healing power with the vigorous positive energy.By revealing the network regulation mechanism of body homeostasis,we can better understand the holistic view and precise intervention of TCM,as well as the therapeutic effects of drugs on diseases through multi-target and multi-organ interventions.The use of cutting-edge neuroscientific thinking and technology to interpret the principles of TCM inspired by the holistic view and systems theory,and the compatibility of clinical TCM with systems biology and other disciplines to establish a new framework for basic and clinical research,will promote the effective integration of the reductionist-oriented modern medical system and the systems-theory-inspired TCM,as well as the application of the theory of visceral manifestation and self-healing system regulation in medicine.

关 键 词：神经—内分泌—免疫网络 中药现代化 藏象学说 自愈体系 

分 类 号：R2-03[医药卫生—中医学]