基于复杂网络社团分析探讨《医宗金鉴》治疗便秘核心用药规律  

Discussion on the core medication law of constipation in the Yi Zong Jin Jian based on the analysis of complex network societies

作　　者：张苗 杨会举[2] 崔伟锋 杨新玉 赵允阳 孙浩格 Miao Zhang;Huiju Yang;Weifeng Cui;Xinyu Yang;Yunyang Zhao;Haoge Sun(College of Acupuncture and Massage,Henan University of Traditional Chinese Medicine,Zhengzhou 450000,China;Department of Anorectal,the Third Affiliated Hospital of Henan University of Traditional Chinese Medicine,Zhengzhou 450008,China;Department of Traditional Chinese Medicine,Integrated Traditional Chinese and Western Medicine Hospital of Henan Province,Zhengzhou 450004,China)

机构地区：[1]河南中医药大学针灸推拿学院,郑州450000 [2]河南中医药大学第三附属医院肛肠科,郑州450008 [3]河南省中西医结合医院中医科,郑州450004

出　　处：《国际中医中药杂志》2024年第7期926-931,共6页International Journal of Traditional Chinese Medicine

基　　金：国家自然科学基金(81774453);河南省中医药拔尖人才项目(豫卫中医函〔2021〕15号);河南省科技攻关项目(222102310417);河南省中医药科学研究专项课题项目(20-21ZY2076);河南省中医药文化与管理研究项目(TCM2023012)。

摘　　要：目的利用数据挖掘技术探讨《医宗金鉴》治疗便秘的核心用药规律,为临床治疗便秘提供思路。方法整理《医宗金鉴》有关便秘的方剂,采用中医传承云计算平台V1.0对数据集进行频次统计、性味归经及功效统计、关联分析和复杂网络分析,并进行可视化展示。结果纳入治疗便秘方剂106首,涉及中药169味,总频次894次,高频中药有大黄、甘草、黄芩、当归等,以泻下药、补虚药、清热药为主,药味以辛、甘、苦为主,药性以寒、温为主,归经以肺、脾、胃、肝经为主。根据关联规则支持度,二阶关联分析得出大黄-黄芩、大黄-芒硝等10个药物组合,三阶关联分析得出大黄-当归-甘草,黄芩-黄连-大黄等9个药物组合,社团聚类分析得出12类聚类方。结论《医宗金鉴》治疗便秘用药遵循"温、清、补"思想,以通降法为主,以温中补虚、清热通便为基本治法,寒温并用,脏腑辨治。临证应以病为纲,辨证施治。Objective To explore the core medication law of constipation in the Yi Zong Jin Jian using data mining techniques;To provide idea for the clinical treatment of constipation.Methods The prescriptions related to constipation in the Yi Zong Jin Jian were summarized,and the frequency statistics,the efficiency statistics of the properties and tastes,correlation analysis and complex network analysis were carried out on the data set using the TCM Inheritance Cloud Platform V1.0,and the visualization was carried out.Results A total of 106 prescriptions for constipation were included,involving 169 kinds of Chinese materia medica,with a total frequency of 894 times.The high-frequency Chinese materia medica included Rhei Radix et Rhizoma,Glycyrrhizae Radix et Rhizoma,Scutellariae Radix and Angelicae Sinensis Radix,etc.Chinese materia medica was mainly composed of purging drugs,tonifying drugs and clearing heat drugs.The main tastes were pungent,sweet and bitter,while the main properties were cold and warm,and the main meridians were lung,spleen,stomach and liver meridians.10 drug combinations such as Rhei Radix et Rhizoma-Scutellariae Radix,Rhei Radix et Rhizoma-Natrii Sulfas were obtained by second-order analysis,9 drug combinations such as Rhei Radix et Rhizoma-Angelicae Sinensis Radix-Glycyrrhizae Radix et Rhizoma,Scutellariae Radix-Coptidis Rhizoma-Rhei Radix et Rhizoma were obtained by third-order analysis,and 12 categories were obtained by community cluster analysis.Conclusions In the treatment of constipation in the Yi Zong Jin Jian,it follows the academic thought of"warming,clearing and tonifying".It focuses on the method of tonifying and lowering,and takes warming and tonifying deficiency,clearing heat and defecating as the basic treatment,with cold and warm drugs,based on syndrome differentiation and treatment of zang-fu organs.When treating,it is required to prioritize the disease and treat it according to the syndrome.

关 键 词：便秘 《医宗金鉴》 复杂网络社团分析 用药规律 数据挖掘 

分 类 号：R256.35[医药卫生—中医内科学]