针灸治疗类风湿关节炎临床及机制研究进展  

Research progress in clinical and mechanism of acupuncture and moxibustion in the treatment of rheumatoid arthritis

作　　者：谢飞 徐枝芳 苑功名 郭永明 徐媛 郭义 赵季宇 吕中茜 李飞洋 李佩云 公一囡 Fei Xie;Zhifang Xu;Gongming Yuan;Yongming Guo;Yuan Xu;Yi Guo;Jiyu Zhao;Zhongqian Lyu;Feiyang Li;Peiyun Li;Yinan Gong(Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China;School of Acupuncture Moxibustion and Tuina,Research Center of Experimental Acupuncture Science,Tianjin University of Traditional Chinese Medicine,Tianjin,China Tianjin Key Laboratory of Innovation and Transformation of Modern Traditional Chinese Medicine Theory,National Clinical Research Center of Acupuncture and Moxibustion,Tianjin 301617,China)

机构地区：[1]天津中医药大学,天津301617 [2]天津中医药大学针灸推拿学院天津中医药大学实验针灸学研究中心、天津市现代中医理论创新转化重点实验室、国家针灸临床医学研究中心,天津301617

出　　处：《国际中医中药杂志》2024年第7期947-951,共5页International Journal of Traditional Chinese Medicine

基　　金：国家自然科学基金(82030125, 82205279);天津市研究生科研创新项目(2022SKY233);天津中医药大学研究生科研创新项目(GYSKC-20221040)。

摘　　要：针刺可改善类风湿关节炎(RA)患者疼痛、关节僵硬等临床症状, 改善类风湿因子、超敏C反应蛋白、ESR等临床指标, 并通过抑制病灶局部关节滑膜细胞增殖及软骨细胞凋亡、抑制肥大细胞炎症反应, 以及脾脏、腘窝淋巴结等上游免疫器官炎症细胞浸润, 调节T细胞极化平衡, 改善RA炎症状态。临床多取足太阳膀胱经、足阳明胃经、足太阴脾经、督脉等治疗, 选穴以足三里、阳陵泉、大椎、曲池等温经散寒通络的穴位为主。近年研究表明, 针药联用的治疗策略值得临床推广。It is found that acupuncture can significantly improve the clinical symptoms of rheumatoid arthritis(RA)such as pain and joint stiffness,and improve rheumatoid factor,high-sensitivity CRP,ESR and other clinical indicators.It can inhibit the proliferation of synovial cells,the apoptosis of chondrocytes,and regulate polarization balabce of mononuclear macrophages,T cells,as well as inhibit the inflammatory function of multiple immune cells,in order to improve inflammation state of RA joints.In clinical treatment of RA,bladder meridian,stomach meridian,spleen meridian,and Governor Vessel are mostly selected.Acupoints with the efficacy of warming meridian,dispelling coldness and dredging collaterals were commonly selected such as Zusanli(ST36),Yanglinquan(GB34),Dazhui(GV14),Quchi(LI11).Several researches have proved that combined therapy of acupuncture and medicine is worthy promotion in clinic.

关 键 词：针灸疗法 类风湿关节炎 免疫细胞 抗炎 综述 

分 类 号：R246.1[医药卫生—针灸推拿学]