垂体功能减退症患者中医证候特点及证型研究  

Study on syndrome characteristics and types of traditional Chinese medicine in patients with hypopituitarism

作　　者：曲笑啸 杨宏杰[2] 陈清光[1] 赵慧敏 李益明 吴蔚[3] 刘晓玉 陆灏[1] 叶红英[3] QU Xiaoxiao;YANG Hongjie;CHEN Qingguang;ZHAO Huimin;LI Yiming;WU Wei;LIU Xiaoyu;LU Hao;YE Hongying(Shuguang Hospital,Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China;Yueyang Hospital of Integrated Traditional Chinese and Western Medicine,Shanghai University of Traditional Chinese Medicine,Shanghai 200437,China;Huashan Hospital,Fudan University,Shanghai 200040,China)

机构地区：[1]上海中医药大学附属曙光医院,上海201203 [2]上海中医药大学附属岳阳中西医结合医院,上海200437 [3]复旦大学附属华山医院,上海200040

出　　处：《中华中医药杂志》2024年第7期3802-3806,共5页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：上海市中医临床重点实验室(No.20DZ2272200);上海市进一步加快中医药传承创新发展三年行动计划(2021年-2023年)项目[No.ZY(2021-2023)-0302];上海市综合医院中西医结合专项一般项目[No.ZY(2018-2020)-FWTX-3009]。

摘　　要：目的:探索垂体功能减退症中医证候特点及证型分布,为中医药辨证论治提供理论依据。方法:采用流行病学调查和多元统计学相结合的方法,采集204例垂体功能减退症患者的症状、舌脉象,运用因子分析对高频症状、舌脉象进行公因子提取,归纳中医病性、病位;运用聚类分析归纳中医证型。结果:频率排名前10的症状分别为倦怠乏力、神疲、咽干、健忘、皮肤干燥/脱屑、夜尿多、腰膝酸软、渴欲饮热、嗜睡、性欲减退。因子分析结合聚类分析获得了4类中医证型:气血两虚证、阴虚血瘀证、气滞痰凝证、阴阳两亏证。结论:垂体功能减退症中医证候特点以虚为本,虚实夹杂,可分为气血两虚证、阴虚血瘀证、气滞痰凝证、阴阳两亏证。Objective:To explore the characteristics and distribution of traditional Chinese medicine(TCM)syndromes of hypopituitarism and provide theoretical basis for TCM syndrome differentiation and treatment.Methods:Using a method that combines epidemiological investigation and multivariate statistics,the symptoms and tongue and pulse conditions of 204 patients with hypopituitarism were collected.Factor analysis was used to extract common factors for high-frequency symptoms and tongue and pulse conditions,and TCM characteristics and locations of the disease were summarized.Cluster analysis was used to summarize TCM syndrome types.Results:The top 10 symptoms were languidness,fatigue,dry pharynx,forgetfulness,dry skin/desquamation,excessive nocturnal urination,sore waist and knees,thirst for hot drinks,lethargy and decreased libido.Four categories of TCM syndromes:qi-blood deficiency syndrome,yin deficiency and blood stasis syndrome,qi stagnation and phlegm coagulation syndrome and yin-yang deficiency syndrome were obtained through factor analysis combined with cluster analysis.Conclusion:The characteristics of TCM syndromes of hypopituitarism are deficiency-based,deficiency and excess mixed,which can be divided into four TCM syndrome types:qi-blood deficiency syndrome,yin deficiency and blood stasis syndrome,qi stagnation and phlegm coagulation syndrome and yin-yang deficiency syndrome.

关 键 词：垂体功能减退症 因子分析 聚类分析 证候特点 中医证型 

分 类 号：R259[医药卫生—中西医结合]