慢性乙型肝炎新型诊断标志物的研发概况  被引量:1

Overview of new diagnostic markers for chronic hepatitis B

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作  者:马亦林[1] Ma Yilin(Department of Infectious Diseases,State Key Laboratory for Diagnosis and Treatment of Infectious Diseases,National Clinical Research Center for Infectious Diseases,the First Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou 310003,China)

机构地区:[1]浙江大学医学院附属第一医院感染病科,传染病重症诊治全国重点实验室,国家感染性疾病临床医学研究中心,杭州310003

出  处:《中华临床感染病杂志》2024年第2期93-98,共6页Chinese Journal of Clinical Infectious Diseases

摘  要:乙型肝炎已成为严重威胁人类健康的世界性疾病,也是我国当前流行广泛、危害性严重的传染病之一。据《中国卫生健康统计年鉴(2022)》数据显示,2021年,我国乙型肝炎发病率为69.25人/10万人。为了使感染科临床工作者获得乙型肝炎研究的前沿信息,本文对乙型肝炎的靶点和新型诊断标志物与病毒复制的相关性、临床意义及检测技术改进等作了重点介绍,建议有条件单位逐步扩大检测,这将对临床诊断率及抗病毒药物评估有帮助,并有助于实现世界卫生组织提出“到2030年乙型肝炎诊断率要提升至90%”的目标。Hepatitis B has become a global disease that seriously threatens human health,and it is also one of the widespread and serous infectious diseases in China.According to China Health Statistical Yearbook(2022),the incidence rate of hepatitis B in China is 69.25/100000 in 2021.This article elaborates the the correlation between viral replication and related novel diagnostic markers of hepatitis virus,the clinical significance and the advances in detection technology of these markers,to provide information for clinician in the field of infectious diseases.It is suggested that the testing for novel hepatitis markers should be expanded in relevant institutions,which will be helpful for clinical diagnosis and antiviral therapy evaluation,to achieve the World Health Organization's goal of increasing hepatitis B diagnosis rate to 90%by 2030.

关 键 词:慢性乙型肝炎 新型诊断标志物 共价闭合环状DNA HBV核糖核酸 HBV核心相关抗原 乙型肝炎核心抗体 

分 类 号:R512.62[医药卫生—内科学]

 

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