不同年龄段儿童甲型流感病毒感染血常规参数的分析及临床意义  

Analysis and clinical significance of routine blood parameters of influenza A virus infection in children of different ages

作　　者：黄雨晴 丘佩琳 范浩林 赖福红 HUANG Yuqing;QIU Peilin;FAN Haolin;LAIFuhong(Department of Pediatrics,Panyu Sixth People's Hospital of Guangzhou,Guangzhou,Guangdong 511442,China)

机构地区：[1]广州市番禺区第六人民医院儿科,广东广州511442

出　　处：《热带医学杂志》2024年第6期838-841,共4页Journal of Tropical Medicine

基　　金：广东省医学科学技术研究基金项目(A2023461)。

摘　　要：目的 探讨广州地区不同年龄段甲型流感病毒阳性儿童血常规参数、中性粒细胞/淋巴细胞比值(NLR)的差异及临床意义,为儿童流感的早期辅助诊断和防治提供参考。方法 回顾性分析2023年4-11月于广州市番禺区第六人民医院就诊的具有流感症状的704例14岁以下儿童的临床资料,根据甲型流感抗原结果分为阳性组(n=192)和阴性组(n=512),对<7岁组(n=208)及7~14岁组(n=496)两个年龄段的儿童血常规参数及NLR分别进行统计分析,并对比两个年龄段组甲型流感阳性儿童血常规参数及NLR的差异。结果 704例患儿中,甲型流感抗原阳性儿童共192例,总阳性率为27.27%。不同性别儿童的甲型流感阳性率比较,差异无统计学意义(χ^(2)=2.823,P=0.093),而7~14岁组甲型流感阳性率(29.84%)高于<7岁组(21.15%),差异有统计学意义(χ^(2)=5.573,P=0.018)。<7岁甲型流感阳性组患儿淋巴细胞计数、淋巴细胞比例、白细胞计数显著低于阴性组,NLR显著高于阴性组,差异均有统计学意义(Z=-4.446、-2.437、-2.395、-2.379,P均<0.05);7~14岁甲型流感阳性组患儿淋巴细胞计数、淋巴细胞比例、中性粒细胞比例显著低于阴性组,NLR显著高于阴性组,差异均有统计学意义(Z=-7.564、-6.149、-4.938、-5.892,P均<0.05)。7~14岁组甲型流感阳性患儿淋巴细胞计数、淋巴细胞比例显著低于<7岁组,中性粒细胞比例、NLR显著高于<7岁组,差异均有统计学意义(Z=-2.529、-2.634、-2.426、-2.603,P均<0.05)。结论 不同年龄段感染甲型流感病毒儿童血常规参数存在差异,结合血常规参数及NLR等指标能够为儿童甲型流感病毒感染和诊断提供参考和提示。Objective To investigate the differences of blood routine parameters, neutrophil/lymphocyte ratio(NLR) of children infected with influenza A virus among different age groups in Guangzhou, China, which would provide reference for early diagnosis and prevention against influenza. Methods From April 2023 to November 2023 in Panyu Sixth People's Hospital of Guangzhou, a total of 704 children aged under 14 years old with flu symptoms were enrolled in this study.According to the results of antigen test of influenza A, patients were divided into positive group(n=192) and negative group(n=512). The blood routine parameters and NLR of children <7 years old group(n=208) and 7-14 years old group(n=496) were statistically analyzed, and the differences of blood routine parameters and NLR of children with positive result were compared between the two age groups. Results Among the 704 cases, 192 children were positive with influenza A antigen,overall positive rate was 27.27%. No statistical difference was observed among gender of children with positive results (χ^(2)=2.823, P=0.093), while the positive rate of influenza A in 7~14 years old group(29.84%) was statistically higher than <7years old group(21.15%);the difference was statistically significant (χ^(2)=5.573, P=0.018). The lymphocyte count, lymphocyte ratio and white blood cell count in positive group of influenza A antigen in <7 years old were significantly lower than negative group, and the NLR was significantly higher than that of negative group;the differences were significant(Z=-4.446,-2.437,-2.395,-2.379;all P<0.05). The lymphocyte count, lymphocyte ratio and neutrophil ratio in positive group of influenza A antigen in 7-14 years old were significantly lower than those of negative group, and the NLR was significantly higher than that of negative group;the differences were significant(Z=-7.564,-6.149,-4.938,-5.892;all P<0.05). The lymphocyte count and lymphocyte ratio in children with positive result of influenza A antigen in 7-14 years old group were significantl

关 键 词：甲型流感病毒 血常规 中性粒细胞/淋巴细胞比值 

分 类 号：R511.7[医药卫生—内科学]