血清VS-2、CTRP9水平对急性心肌梗死患者PCI术后心力衰竭的预测价值  

The predictive value of serum VS-2 and CTRP9 levels on heart failure after PCI in patients with acute myocardial infarction

作　　者：郭双 苏丽萍 胡丽君 GUO Shuang;SU Liping;HU Lijun(Department of Clinical Laboratory,Hubei Jianghan Oilfield General Hospital,Qianjiang,Hubei 433100,China;Department of Cardiology,Hubei Jianghan Oilfield General Hospital,Qianjiang,Hubei 433100,China)

机构地区：[1]湖北江汉油田总医院检验科,湖北潜江433100 [2]湖北江汉油田总医院心内科,湖北潜江433100

出　　处：《热带医学杂志》2024年第6期872-875,883,I0003,共6页Journal of Tropical Medicine

基　　金：湖北省教育科学“十二五”规划2011年度立项课题(2011B190)。

摘　　要：目的 通过对急性心肌梗死(AMI)患者进行长期随访和生物标志物检测,探讨血清血管抑制因子(VS-2)、C1q/肿瘤坏死因子相关蛋白9(CTRP9)水平与经皮冠状动脉介入(PCI)术后心力衰竭(HF)之间的关系,以评估其在临床预测中的潜在价值。方法 选取2019年1月-2022年1月在湖北江汉油田总医院行PCI术治疗的AMI患者96例作为研究对象,术后随访1年,发生HF 27例(HF组)、未发生HF 69例(非HF组)。收集患者临床资料,采用酶联免疫吸附试验检测血清VS-2、CTRP9水平。多元logistic回归分析AMI患者PCI术后并发HF的独立影响因素,并绘制受试者工作特征(ROC)曲线分析VS-2、CTRP9对AMI患者PCI术后HF的预测价值。结果 HF组血清VS-2、CTRP9水平[(16.83±4.22)pg/L、(9.25±2.49)ng/mL]低于非HF组[(25.06±6.68)pg/L、(12.62±3.03)ng/mL],差异均有统计学意义(t=5.944、5.136,P均<0.01)。多元logistic回归分析显示,VS-2、CTRP9是AMI患者PCI术后并发HF的独立影响因素,差异均有统计学意义(OR=2.462、1.388,P均<0.01)。ROC曲线分析显示,VS-2、CTRP9及二者联合检测预测AMI患者PCI术后并发HF的曲线下面积分别为0.816、0.784、0.883,以二者联合检测预测价值最高。结论 血清VS-2、CTRP9水平降低与HF的发生相关,联合检测这两个生物标志物能够更准确地预测AMI患者PCI术后并发HF的风险。Objective Through long-term follow-up and biomarker detection in patients with acute myocardial infarction(AMI), the relationship between serum levels of vascular suppressor factor(VS-2), C1q/tumor necrosis factor-related protein 9(CTRP9) and heart failure(HF) after percutaneous coronary intervention(PCI) was explored to evaluate its potential value in clinical prediction. Methods A total of 96 patients with AMI who underwent PCI in Hubei Jianghan Oilfield General Hospital from January 2019 to January 2022 were selected as the study subjects. After 1 year of follow-up, 27 patients had HF(HF group) and 69 patients had no HF(non-HF group). The clinical data of patients were collected, and the levels of serum VS-2 and CTRP9 were detected by enzyme-linked immunosorbent assay. Multivariate logistic regression analysis was used to analyze the independent influencing factors of HF after PCI in AMI patients, and the receiver operating characteristic(ROC) curve was drawn to analyze the predictive value of VS-2 and CTRP9 for HF after PCI in AMI patients.Results The serum VS-2 and CTRP9 levels in the HF group [(16.83±4.22)pg/L,(9.25±2.49)ng/mL] were lower than those in the non-HF group [(25.06±6.68)pg/L,(12.62±3.03)ng/mL];the differences were statistically significant(t=5.944, 5.136,both P<0.01). Multiple logistic regression analysis showed that VS-2 and CTRP9 were independent influencing factors of HF after PCI in AMI patients, and the differences were statistically significant(OR=2.462, 1.388;both P<0.01). ROC curve analysis showed that the areas under the curve of VS-2, CTRP9 and their combination in predicting HF after PCI in AMI patients were 0.816, 0.784 and 0.883, respectively, with the combination of the two having the highest predictive value. Conclusions Reduced serum VS-2 and CTRP9 levels were related to the occurrence of HF.Joint detection of these two biomarkers could more accurately predict the risk of HF in AMI patients after PCI.

关 键 词：急性心肌梗死 经皮冠状动脉介入 心力衰竭 血管抑制因子 C1q/肿瘤坏死因子相关蛋白9 

分 类 号：R542.22[医药卫生—心血管疾病] R541.6[医药卫生—内科学]