A Study on the Association Between Siglec-1 Gene Polymorphism and Susceptibility in Patients with Chronic Obstructive Pulmonary Disease in Luohe Area  

作　　者：Juan Cao Chun'e Wang Bing Zhao Yi Zheng Sensen Li 

机构地区：[1]School of Medicine of Huanghuai University,Zhumadian 463000,Henan Province,China [2]Affiliated Zhumadian Central Hospital of Huanghuai University,Zhumadian 463000,Henan Province,China [3]Jiyang District People's Hospital,Jinan 251400,Shandong Province,China

出　　处：《Journal of Clinical and Nursing Research》2024年第6期1-9,共9页临床护理研究（英文）

基　　金：Henan Province Science and Technology Research and Development(222102310510);Henan Province Medical Science and Technology Research Project(LHGJ20200890)。

摘　　要：Objective:To analyze the association between Siglec-1 gene polymorphism and susceptibility to chronic obstructive pulmonary disease(COPD)in the population of the Luohe area.Methods:A case-control study(150 COPD patients and 150 healthy controls)was conducted to analyze the Siglec-1 allele in two groups of individuals using single nucleotide polymorphism(SNP)high-throughput detection technology,and the frequencies of each allele were compared.Results:The frequency of rs611847 heterozygous A/G genotype in COPD patients was significantly lower in females than in healthy controls(OR=0.282,95%CI=0.085-0.938,P=0.039);among smokers,the frequency of rs3859664 and rs6084444 genotypes in COPD patients was significantly higher than that in the healthy control group(OR=2.028,95%CI=1.111-3.704,P=0.021;OR=1.836,95%CI=1.033-3.262,P=0.038).Conclusion:Among the COPD population in the Luohe area,there is a significant correlation between the genotypes of three SNPs loci,rs3859664,rs6084444,and rs611847 and susceptibility to COPD in different subgroups of the population.The rs3859664 A/G-A/A and rs6084444 A/G-G/G genotypes can increase the risk of COPD in smokers;the rs611847 heterozygous A/G genotype can reduce the risk of COPD in both female and smoking populations.

关 键 词：Chronic obstructive pulmonary disease Siglec-l Gene frequency 

分 类 号：R56[医药卫生—呼吸系统]