多巴丝肼联合重复经颅直流电刺激治疗对帕金森疾病患者运动和非运动功能的影响  

Influence of levodopa and benserazide combined with repetitive transcranial direct current stimulation therapy on motor function and non-motor function in patients with Parkinson's disease

作　　者：康乐乐 苗婵婵 高海茸 KANG Le-le;MIAO Chan-chan;GAO Hai-rong(Department of Neurology,Affiliated Hospital of Yan'an University;Department of Neurology,Yan'an People's Hospital,Yan'an 716000,Shaanxi,China)

机构地区：[1]延安大学附属医院神经内科 [2]延安市人民医院神经内科,陕西延安716000

出　　处：《川北医学院学报》2024年第8期1059-1063,共5页Journal of North Sichuan Medical College

基　　金：陕西省重点研发计划项目(S2021-YF-YBSF-0491)。

摘　　要：目的:探讨多巴丝肼联合重复经颅直流电刺激(rTMS)治疗对帕金森疾病(PD)患者运动和非运动功能的影响。方法:选取96例PD患者为研究对象,根据治疗方案不同分为单一组和联合组,每组各48例。单一组患者口服多巴丝肼治疗;联合组患者在对照组基础上给予rTMS治疗,两组患者疗程均为2个月。比较两组患者临床疗效[帕金森评估量表(UPDRS)评分)]、运动能力[Barthel指数、肌张力(MAS)]、认知能力[(蒙特利尔认知评估量表(MoCA)评分)、大脑皮质兴奋性指标[动作诱发电位(MEP)、静息运动阈值(RMT)]、生活质量[生活质量评估量表(GQOL-74)评分]及不良反应发生情况。结果:治疗后,两组患者UPDRS评分、MAS、RMT均下降(P<0.05),且联合组低于单一组(P<0.05);Barthel指数、MoCA、MEP、GQOL-74评分均上升(P<0.05),且联合组高于单一组(P<0.05);两组患者不良反应总发生率无统计学差异(P>0.05)。结论:rTMS联合多巴丝肼可有效改善PD患者运动功能、认知功能及大脑皮质兴奋性,提高生活质量,且安全性高,值得临床推广。Objective:To explore the influence of levodopa and benserazide combined with repetitive transcranial direct current stimulation(rTMS)on motor and non-motor functions in patients with Parkinson's disease(PD).Methods:96 patients with PD were selected as the research subjects,and they were divided into single group and combined group according to different treatment regimens,with 48 cases in each group.The single group was orally administered with levodopa and benserazide,while the combined group was given rTMS therapy on this basis,the treatment course for both groups was 2 months.The clinical efficacy(UPDRS),and motor ability[Barthel index,muscle tension(MAS)],cognitive ability(MoCA),cerebral cortical excitability indicators[motor evoked potential(MEP),resting motor threshold(RMT)],quality of life(GQOL-74),and adverse reactions were compared between the two groups.Results:After treatment,the UPDRS,MAS and RMT in both groups were decreased(P<0.05),and the above indicators in combined group were lower than those in single group(P<0.05).The Barthel index,MoCA,MEP and GQOL-74 were increased in both groups(P<0.05),and the combined group had higher indicators(P<0.05).There were no significant differences in the incidence rates of adverse reactions between the two groups(P>0.05).Conclusion:rTMS combined with levodopa and benserazide can improve the motor function,cognitive function and cerebral cortical excitability and enhance the quality of life in patients with PD,and it has high safety,which is worthy of clinical promotion.

关 键 词：多巴丝肼 重复经颅直流电刺激 帕金森病 运动能力 

分 类 号：R454.1[医药卫生—治疗学]