中低频超声肝部肿瘤消融治疗仪的研制  

Development of a mid-to-low frequency ultrasound ablation therapy instrument for liver tumors

作　　者：刘细宝 张晓娜 李琦 王钊利 陈立新 LIU Xibao;ZHANG Xiaona;LI Qi;WANG Zhaoli;CHEN Lixin(Hangzhou Ruili Ultrasonic Technology Co.,Ltd,Hangzhou 310023,China;The Second Af filiated Hospital Zhejiang University School of Medicine,Hangzhou 310023,China)

机构地区：[1]杭州瑞利超声科技有限公司,浙江杭州310023 [2]浙江大学医学院附属第二医院,浙江杭州310009

出　　处：《杭州电子科技大学学报(自然科学版)》2024年第3期23-32,共10页Journal of Hangzhou Dianzi University:Natural Sciences

基　　金：福建省科技厅社会发展重大专项揭榜挂帅项目(2021YZ036017)。

摘　　要：设计带有中低频超声换能器探头的超声肿瘤消融治疗仪,来研究中低频非聚焦超声对肝部肿瘤组织的疗效影响。其中低频超声换能器的结构为效率较高的对称纵振结构且频率设计为20 kHz,中频超声换能器的结构设计为多阶弯曲式复合振子且频率设计为1 MHz;二者经相应的驱动电路后,中频换能器对浅表肿瘤组织辐射声波,低频换能器对深部肿瘤组织辐射声波。经小白鼠动物实验后发现,肝部肿瘤组织明显坏死并减小,而其余组织未见明显异常。结果表明,中低频非聚焦超声可有效消融实质性肿瘤组织且安全副作用小。In order to study the therapeutic effect of mid-to-low frequency non focused ultrasound on tumor tissue,an ultrasound tumor treatment instrument with mid-to-low frequency ultrasound transducer probes was designed.The structure of the low-frequency ultrasound transducer was a symmetrical longitudinal vibration structure with high efficiency of 20 kHz;the structural design of the intermediate frequency ultrasonic transducer is a curved disc composite oscillator with a frequency of 1 MHz.After passing through the corresponding driving circuit,the intermediate frequency transducer radiated sound waves to shallow tumor tissue,and the low-frequency transducer radiated sound waves to deep tumor tissue.Animal experiments in mice found that the liver tumor tissue was significantly necrotic and reduced,while no significant abnormalities were observed in the other tissues.The results indicate that mid-to-ow frequency non focused ultrasound can effectively ablate solid tumor tissue with sufficient safety and minimal side effects.

关 键 词：超声消融 超声治疗 肿瘤消融 肝部肿瘤 肿瘤治疗 

分 类 号：TP29[自动化与计算机技术—检测技术与自动化装置]