孕早期空腹血糖与妊娠期糖尿病的相关性研究  

Correlation between Fasting Plasma Glucose in Early Pregnancy and Gestational Diabetes Mellitus

作　　者：韩文莉[1] 陈奕[1] HAN Wenli;CHEN Yi(Beijing Obstetrics and Gynecology Hospital,Capital Medical University,Beijing Maternal and Child Health Care Hospital,Perinatal Medicine Department,Beijing 100026,China)

机构地区：[1]首都医科大学附属北京妇产医院北京妇幼保健院围产医学部,北京100026

出　　处：《实用妇产科杂志》2024年第7期582-585,共4页Journal of Practical Obstetrics and Gynecology

摘　　要：目的:探讨孕早期空腹血糖(FPG)与妊娠期糖尿病(GDM)发生风险的关系。方法:回顾性分析2017年6月1日至2017年12月31日于首都医科大学附属北京妇产医院分娩的1044例单胎初孕妇的孕早期临床数据资料。根据是否诊断为GDM,分为GDM组(n=173)和非GDM组(n=871),采用单因素和多因素回归分析孕早期FPG与GDM发生的关系。结果:1044例单胎孕妇中,173例诊断为GDM(16.6%)。GDM组年龄、孕前BMI、孕早期FPG均显著高于非GDM组,差异有统计学意义(P<0.05)。调整年龄、孕前BMI和血脂指标后,多因素Logistics回归分析结果显示孕早期FPG是GDM发生的独立危险因素(OR>1,P<0.05)。当以FPG<5.1 mmol/L为参考,FPG≥5.1 mmol/L时GDM发生风险增加3.26倍(OR 3.26,95%CI 2.20~4.84,P<0.001)。结论:孕早期FPG是影响GDM发生的独立危险因素,孕早期FPG水平升高与GDM发生显著相关。Objective:To investigate the relationship between fasting plasma glucose(FPG)in early pregnancy and the risk of gestational diabetes mellitus(GDM).Methods:A retrospective analysis was conducted on the early pregnancy clinical data of 1044 singleton pregnant women who delivered between June 1,2017 and December 31,2017 in Beijing Obstetrics and Gynecology Hospital,Capital Medical University.According to whether diagnosed with GDM or not,they were divided into GDM group(n=173)and non GDM group(n=871).Univariate and multivariate regression analyses were used to examine the association of FPG in the first trimester with GDM occurrence.Results:Among the 1044 pregnant women in the study,173(16.6%)were diagnosed with GDM.The age,pre pregnancy BMI,and early pregnancy FPG of the GDM group were significantly higher than those of the non GDM group,and the differences were statistically significant(P<0.05).After adjusting for age,pre-pregnancy BMI and blood lipid index,the results of multivariate Logistic regression analysis showed that FPG in the first trimester was an independent risk factor for GDM occurrence(OR>1,P<0.05).Using FPG<5.1 mmol/L as a reference,when FPG≥5.1 mmol/L,the risk of GDM occurrence increased by 3.26 times(OR 3.26,95%CI 2.20-4.84,P<0.001).Conclusions:FPG in the first trimester is an independent risk factor for the occurrence of GDM.The increase of FPG level in the first trimester is significantly correlated with the occurrence of GDM.

关 键 词：妊娠期糖尿病 空腹血糖 危险因素 

分 类 号：R714.256[医药卫生—妇产科学]