载黄芪甲苷的核壳结构纳米纤维创面敷料的制备及性能  

Preparation and Performance of Astragaloside-Loaded Core-Shell Nanofiber Wound Dressing

作　　者：王红伟 王立红 刘泽梅 罗永明 康致超 车鑫 WANG Hongwei;WANG Lihong;LIU Zemei;LUO Yongming;KANG Zhichao;CHE Xin(School of Pharmacy,Guizhou University of Traditional Chinese Medicine,Guizhou 550025,China)

机构地区：[1]贵州中医药大学药学院,贵州550025

出　　处：《功能高分子学报》2024年第4期338-346,共9页Journal of Functional Polymers

基　　金：贵州省科技厅基础研究计划项目(黔科合基础-ZK[2024]一般394);贵州省卫健委科技基金项目(GZWKJ2022-233);贵州省卫健委科学技术基金项目(zwkj2022-234);贵州省中医药管理局科学技术基金项目(QZYY-2020-039)。

摘　　要：采用静电纺丝技术制备同轴黄芪甲苷(AS)/聚乙烯吡咯烷酮(PVP)/聚乳酸(PLA)纳米纤维功能敷料。对纳米纤维的微观形貌、原料与辅料间化学相互作用、润湿性、水蒸气透过率、抗氧化、抗菌及促糖尿病创面愈合等性能进行研究。结果表明,AS/PVP/PLA纳米纤维有明显的核壳结构,纤维直径为(480±240)nm、接触角为(88.73±1.07)°、水蒸气透过率为(1660.42±80.61)g/(m^(2)·d)、自由基清除率为47%,对大肠杆菌、金黄色葡萄球菌均有明显的抑菌作用。促糖尿病创面愈合结果表明,第14 d时糖尿病大鼠的创面愈合率达到(99.75±0.05)%。Coaxial astragaloside(AS)/polyvinylpyrrolidone(PVP)/polylactic acid(PLA)nanofiber functional dressings(AS/PVP/PLA)were prepared by coaxial electrostatic spinning technique.The micro-morphology,wettability,water vapor transmission rate and other properties of nanofiber dressings were characterized.The antioxidant capacity,antibacterial effect,and pro-diabetic chronic wound healing effect of the nanofiber dressings were also investigated.Results showed that the coaxial AS/PVP/PLA nanofiber functional dressing had an obvious core-shell structure and a smooth fiber surface,with a fiber diameter of(480±240)nm,a contact angle of(88.73±1.07)°,a water vapor transmission rate of(1660.42±80.61)g/(m^(2)·d),and a free radical scavenging rate of 47%.AS/PVP/PLA nanofiber functional dressing significantly inhibited the growth of Escherichia coli and Staphylococcus aureus,and had a certain pro-healing effect on diabetic chronic wounds.The nanofiber dressings had good morphology and met the requirements,and had the potential to be developed as dressings for diabetic chronic wound healing.

关 键 词：静电纺丝 聚乙烯吡咯烷酮 聚乳酸 黄芪甲苷 创面敷料 

分 类 号：R318.08[医药卫生—生物医学工程] TB34[医药卫生—基础医学]