组蛋白乳酸化与疾病关系研究进展  

Research progress on relationship between histone lactation and disease

作　　者：匡贤栋 蔡馨[1] 汤冬玲[1] 张平安[1] KUANG Xiandong;CAI Xin;TANG Dongling;ZHANG Ping'an(Department of Clinical Laboratory,the People's Hospital of Wuhan University,Wuhan 430060,Hubei,China)

机构地区：[1]武汉大学人民医院检验科,湖北武汉430060

出　　处：《检验医学》2024年第7期704-708,共5页Laboratory Medicine

摘　　要：组蛋白是染色质的主要蛋白组分,对生物遗传信息的调控有重要作用。乳酸作为细胞代谢的常见产物,可影响细胞遗传信息的表达。组蛋白在相关酶的作用下,会发生多种基团的化学修饰,其中乳酸化是重要的化学修饰之一。文章主要综述了组蛋白乳酸化的发生及其影响因素、组蛋白乳酸化与常见疾病的相互关系及治疗相关的研究进展。Histones are the main protein components of chromatin and play roles in the regulation of biological genetic information.As a common product of cell metabolism,lactic acid can affect the expression of cell genetic information.Under the action of related enzymes,histones can undergo chemical modifications of various groups,among which lactation is one of the important chemical modifications.This review mainly focuses on the occurrence and influencing factors of histone lactation,the relationship between histone lactation and common diseases and the research progress of treatment.

关 键 词：组蛋白 乳酸化修饰 疾病 

分 类 号：R446.1[医药卫生—诊断学]