两例Ln_(3)~Ⅲ配合物的构筑、晶体结构及生物活性  

Construction,crystal structures,and biological activities of two LnⅢ3 complexes

作　　者：王海堂 凌妍妮 马夏清 陈雨鑫 张瑞 王可怡 张莹 王文敏 WANG Haitang;LING Yanni;MA Xiaqing;CHEN Yuxin;ZHANG Rui;WANG Keyi;ZHANG Ying;WANG Wenmin(Department of Energy Chemistry and Materials Engineering,Shanxi Institute of Energy,Jinzhong,Shanxi 030600,China;College of Chemistry and Materials,Taiyuan Normal University,Jinzhong,Shanxi 030619,China)

机构地区：[1]山西能源学院能源化学与材料工程系,晋中030600 [2]太原师范学院化学与材料学院,晋中030619

出　　处：《无机化学学报》2024年第8期1474-1482,共9页Chinese Journal of Inorganic Chemistry

基　　金：山西省高校科技创新项目(No.2021L404)资助。

摘　　要：利用多齿席夫碱配体H_(2)L(H_(2)L=(E)-6-(羟甲基)-N'-((6-甲氧基吡啶-2-基)亚甲基)吡啶酰肼)与Ln(dbm)_(3)·2H_(2)O反应,通过溶剂热法,设计与构筑了2例新的三核稀土配合物[Ln_(3)(dbm)_5(L)_(2)(CH_(3)OH)_(2)]·CH_(2)Cl_(2),其中Ln=Pr(1)、Ho(2),Hdbm=二苯甲酰甲烷。单晶X射线衍射分析表明:配合物1与2同构,其结构由3个Ln(Ⅲ)离子、5个二苯甲酰甲烷阴离子(dbm^(-))、2个席夫碱配体L^(2-)、2个配位的CH_(3)OH及1个结晶CH_(2)Cl_(2)分子组成。3个中心Ln(Ⅲ)离子通过4个μ_(2)-O原子相互连接,形成折线形的Ln_(3)核。生物活性研究表明,配体H_(2)L、Ln(dbm)_(3)·2H_(2)O及配合物1和2均具有较好的抑菌活性。与配体H_(2)L及Ln(dbm)_(3)·2H_(2)O相比较,稀土配合物具有更强的抑菌活性。此外,采用紫外光谱法、循环伏安法和荧光光谱法研究了配合物1和2与小牛胸腺DNA(ctDNA)之间的相互作用,结果表明配合物主要以插入键合的方式与ctDNA结合。Two new trinuclear Ln⁃based complexes with the formula[Ln_(3)(dbm)_(5)(L)_(2)(CH_(3)OH)_(2)]·CH_(2)Cl_(2)(Ln=Pr(1),Ho(2);Hdbm=dibenzoylmethane)have been constructed via the solvothermal method by using a polydentate Schiff base ligand H_(2)L(H_(2)L=(E)⁃6⁃(hydroxymethyl)⁃N'⁃((6⁃methoxypyridin⁃2⁃yl)methylene)picolinohydrazide)reacting with Ln(dbm)_(3)·2H_(2)O.Single⁃crystal X⁃ray diffraction reveals that complexes 1 and 2 are isostructural,and their structures are mainly composed of three Lnions,five dbm^(-)ions,two L2-ions,two coordinated CH_(3)OH molecules,and one lattice CH_(2)Cl_(2) molecule.The three central Lnions are connected by fourμ2⁃O atoms forming a folded Ln3 core.Notably,complexes 1 and 2 show promising antibacterial activity and exhibit stronger bacteriostatic activities compared to their precursor components.Additionally,their interaction with calf thymus DNA(ctDNA)was studied using ultraviolet spectroscopy,cyclic voltammetry,and fluorescence spectroscopy,demonstrating their ability to bind to ctDNA mainly by intercalation.CCDC:2258496,1;2258495,2.

关 键 词：稀土配合物 席夫碱配体 晶体结构 生物活性 DNA作用 

分 类 号：O614.334[理学—无机化学] O614.343[理学—化学]