磁性纳米Fe_(3)O_(4)的氧化共沉淀法制备及催化性能  

Preparation and catalytic performance of magnetic nano iron oxide by oxidation co-precipitation method

作　　者：侯思宇 李玮瑶 刘家东 王斐 柳雯思 杨静[1] 张莹[1] HOU Siyu;LI Weiyao;LIU Jiadong;WANG Fei;LIU Wensi;YANG Jing;ZHANG Ying(Shenyang Pharmaceutical University,Benxi,Liaoning 117004,China)

机构地区：[1]沈阳药科大学,本溪117004

出　　处：《无机化学学报》2024年第8期1577-1582,共6页Chinese Journal of Inorganic Chemistry

基　　金：辽宁省教育厅基本科学研究项目(No.LJKMZ20221361);辽宁省普通高等教育本科教学改革研究项目(No.52810163);沈阳药科大学大学生创新创业项目(No.X202310163108、X202310163106)资助。

摘　　要：以单一Fe^(2+)作为铁源,0.4%的H_(2)O_(2)为氧化剂,NaOH为沉淀剂,采用氧化共沉淀法制备了尺寸为7 nm的Fe_(3)O_(4)颗粒。为进一步体外模拟肿瘤饥饿治疗,设计了一个包含5 mL(10 μg·mL^(-1))的葡萄糖氧化酶和15 mL(5 mg·mL^(-1))葡萄糖溶液的体系,以探究纳米Fe_(3)O_(4)的类过氧化氢酶(CAT)与类过氧化物酶(POD)催化性能的最适条件。结果表明:在1 mg·mL^(-1) pH=5.0时,纳米Fe_(3)O_(4)的类CAT活性能推动葡萄糖氧化反应的反应速度增加、限度增大;pH=5.0时,纳米Fe_(3)O_(4)的类POD活性更好,能高效率催化H_(2)O_(2)产生活性氧。Iron oxide particles with a size of 7 nm were prepared by the oxidation co-precipitation method using Fe^(2+)as an iron source,0.4%H_(2)O_(2) as an oxidant,and NaOH as a precipitator.This experiment further simulated tumor starvation therapy in vitor:in 5 mL(10μg·mL^(-1))of glucose oxidase and 15 mL(5 mg·mL^(-1))of glucose solution system,to explore the optimal conditions for the catalytic performance of catalase(CAT)-like and peroxidase(POD)like of nano ferrous oxide.The results showed that under 1 mg·mL^(-1),at pH=5.0,the CAT-like activity of nano Fe_(3)O_(4) can promote an increase in the reaction rate and limit of glucose oxidation reaction;at pH=5.0,the POD-like activity of nano iron oxide was better.It can catalyze hydrogen peroxide to produce reactive oxygen species with high efficiency.

关 键 词：纳米Fe_(3)O_(4) 氧化共沉淀法 催化性能 肿瘤饥饿治疗 活性氧 

分 类 号：O614.123[理学—无机化学]