子宫动脉超声血流参数、血清LncRNA FAM99A、CCL21水平与妊娠期高血压疾病患者病情程度及预后的相关性分析  

Correlation analysis of uterine artery ultrasound blood flow parameters,serum LncRNA FAM99A and CCL21 levels with the severity and prognosis of hypertensive diseases in pregnancy

作　　者：袁梅 刘芳 孙改艳 YUAN Mei;LIU Fang;SUN Gaiyan(Department of Ultrasound,Kaifeng Third People's Hospital,Kaifeng 475100,China;Department of Ultrasound,Kaifeng Central Hospital,Kaifeng 475100,China)

机构地区：[1]开封市第三人民医院超声科,河南开封475100 [2]开封市中心医院超声科,河南开封475100

出　　处：《黑龙江医药科学》2024年第4期24-28,共5页Heilongjiang Medicine and Pharmacy

基　　金：河南省医学科技攻关计划联合共建项目,编号:LHGJ20221053。

摘　　要：目的:探讨妊娠期高血压疾病(hypertensive disorders of pregnancy,HDP)患者子宫动脉超声血流参数、血清长链非编码RNA家族成员A序列相似性99(LncRNA FAM99A)、CC趋化因子配体21(CCL21)水平变化,并分析其与病情程度相关性及其对预后的评估价值。方法:回顾性选取2021年1月至2023年12月于开封市第三人民医院诊治的126例HDP患者作为研究组,另选取健康孕产妇42例作为对照组。比较两组不同病情程度者子宫动脉超声血流参数[子宫动脉收缩期/舒张期血流最大速度(systolic/diastolic,S/D)、子宫动脉阻力指数(resistance index,RI)、子宫动脉搏动指数(pulsation index,PI)]、血清LncRNA FAM99A、CCL21水平。分析子宫动脉超声血流参数、血清LncRNA FAM99A、CCL21与病情程度相关性。依据预后情况分为预后不良亚组27例、预后良好亚组99例,比较其子宫动脉超声血流参数、血清LncRNA FAM99A、CCL21水平。分析预后不良的影响因素。评价子宫动脉超声血流参数、血清LncRNA FAM99A、CCL21对预后不良的评估价值。结果:研究组S/D、RI、PI及血清CCL21水平高于对照组,血清LncRNA FAM99A水平低于对照组(P<0.05);S/D、RI、PI、CCL21与病情程度呈正相关(r=0.526、0.418、0.509、0.624,P<0.05),LncRNA FAM99A与病情程度呈负相关(r=-0.637,P<0.05);预后不良亚组S/D、RI、PI及血清CCL21水平高于预后良好亚组,血清LncRNA FAM99A水平低于预后良好亚组(P<0.05);S/D、RI、PI、CCL21为预后不良的危险因素,LncRNA FAM99A为预后不良的保护因素(P<0.05);S/D、RI、PI、LncRNA FAM99A、CCL21联合评估预后的AUC大于单项指标评估(P<0.05)。结论:HDP患者S/D、RI、PI及血清CCL21水平升高,血清LncRNA FAM99A水平降低,且与病情程度及预后密切相关,联合检测其水平对预后具有一定评估价值。Objective:To investigate the changes of uterine artery ultrasound blood flow parameters,serum long non-coding RNA family member A sequence similarity 99(LncRNA FAM99A),CC chemokine ligand 21(CCL21)levels in patients with hypertensive diseases of pregnancy(HDP),and to analyze their correlation with the severity of the disease and their evaluation value for prognosis.Methods:A total of 126 patients with HDP treated in Kaifeng Third People's Hospital from January 2021 to December 2023 were selected as the study group,and 42 healthy pregnant women were selected as the control group.Uterine artery ultrasound blood flow parameters[maximum systolic/diastolic blood flow velocity(S/D),uterine artery resistance index(RI),uterine artery pulsation index(PI)],serum LncRNA FAM99A and CCL21 levels were compared between the two groups and the study group with different disease stages.The correlation of blood flow parameters,serum LncRNA FAM99A and CCL21 with the severity of the disease was analyzed.According to the prognosis,the patients were divided into poor prognosis subgroup(27 cases)and good prognosis subgroup(99 cases).The uterine artery ultrasound blood flow parameters,serum LncRNA FAM99A and CCL21 levels were compared.The influencing factors of poor prognosis were analyzed.To evaluate the value of uterine artery ultrasound blood flow parameters,serum LncRNA FAM99A and CCL21 for poor prognosis.Results:The levels of S/D,RI,PI and serum CCL21 in the study group were higher than those in the control group,and the levels of serum LncRNA FAM99A were lower than those in the control group(P<0.05).S/D,RI,PI,CCL21 were positively correlated with the severity of the disease(r=0.526,0.418,0.509,0.624,P<0.05),and LncRNA FAM99A was negatively correlated with the severity of the disease(r=-0.637,P<0.05).The levels of S/D,RI,PI and CCL21 in poor prognosis subgroup were higher than those in good prognosis subgroup,and the levels of LncRNA FAM99A in poor prognosis subgroup were lower than those in good prognosis subgroup(P<0.05).S/D,RI,PI

关 键 词：妊娠期高血压疾病 子宫动脉超声血流参数 长链非编码RNA家族成员A序列相似性99 CC趋化因子配体21 预后 

分 类 号：R714.246[医药卫生—妇产科学]