扶正固本汤对胆总管结石术后患者胆汁生化指标及肝功能的影响  

The Influence of Decoction for Reinforcing the Healthy and Strengthening the Base on the Biochemical Indicators of Bile and Liver Function in Patients文献标志码:A After Cholecystectomy for Common Bile Duct Stones

作　　者：魏光亚 张雨 刘鹏[1] 潘徐彪 郭伟胜 WEI Guangya;ZHANG Yu;LIU Peng;PAN Xubiao;GUO Weisheng(The Second Affiliated Hospital of Henan University of Chinese Medicine,Henan Province Hospital of Traditional Chinese Medicine,Zhengzhou,Henan,China,450002)

机构地区：[1]河南中医药大学第二附属医院,河南省中医院,河南郑州450002

出　　处：《河南中医》2024年第8期1230-1234,共5页Henan Traditional Chinese Medicine

基　　金：河南省医学科技攻关计划联合共建项目(LHGJ20210221)。

摘　　要：目的:观察扶正固本汤对胆总管结石术后患者肝功能及胆汁生化指标的影响。方法:选取2019年9月至2023年9月行胆总管探查取石术的患者134例,按照随机数字表法分为对照组和观察组,每组各67例。对照组术后给予常规治疗,观察组则给予扶正固本汤治疗。比较两组患者的临床疗效、不良反应发生率及治疗前后中医证候积分、肝功能指标[谷丙转氨酶(alanine transaminase,ALT)、谷草转氨酶(aspartateaminotransferase,AST)、γ-谷氨酰转肽酶(γ-GT)]、胆汁生化指标[总胆红素(total bilirubin,TBIL)、总胆汁酸(total bile acid,TBA)]。结果:两组患者发热、腹痛、黄疸等中医证候积分低于本组治疗前,且治疗后观察组低于对照组(P<0.05)。观察组有效率高于对照组,差异具有统计学意义(P<0.05)。两组患者治疗后AST、ALT以及γ-GT低于本组治疗前,且治疗后观察组低于对照组,差异具有统计学意义(P<0.05)。两组患者治疗后TBA高于本组治疗前,TBIL低于本组治疗前,且治疗后组间比较,差异具有统计学意义(P<0.05)。观察组不良反应发生率低于对照组(P<0.05)。结论:扶正固本汤运用于胆总管结石手术后,能明显提高临床疗效,改善患者肝功能及胆汁生化指标,降低不良反应。Objective:To observe the influence of Decoction for Reinforcing the Healthy and Strengthening the Base on the biochemical indicators of bile and liver function in patients after cholecystectomy for common bile duct stones.Methods:A total of 134 patients who underwent common bile duct exploration and stone removal surgery from September 2019 to September 2023 were selected and randomly divided into the control group and the observation group,with 67 cases in each group according to the random number table method.The control group received routine treatment after surgery,while the observation group received treatment with Decoction for Reinforcing the Healthy and Strengthening the Base.The clinical efficacy,incidence of adverse reactions,and the changes in TCM syndrome scores,liver function indicators[including alanine transaminase(ALT),aspartate aminotransferase(AST),γ-glutamyl transpeptidase(γ-GT)],and bile biochemical indicators[including total bilirubin(TBIL),total bile acid(TBA)]before and after treatment between the two groups were compared.Results:The TCM syndrome scores,such as fever,abdominal pain,and jaundice in the two groups were lower than those before treatment,and the observation group′s above indicators were lower than those of the control group after treatment(P<0.05).The effective rate of the observation group was higher than that of the control group,and the difference was statistically significant(P<0.05).After treatment,the AST,ALT,andγ-GT levels of the two groups were lower than those before treatment,and the observation group′s above levels were lower than those of the control group,and all the differences were statistically significant(P<0.05);the TBA of the two groups was higher than that before treatment,while the TBIL was lower than that before treatment,and all the differences were statistically significant(P<0.05).The incidence of adverse reactions in the observation group was lower than that in the control group(P<0.05).Conclusion:The application of Decoction for Reinforcing the

关 键 词：胆总管结石 扶正固本汤 谷丙转氨酶 谷草转氨酶 Γ-谷氨酰转肽酶 总胆红素 总胆汁酸 

分 类 号：R259.75[医药卫生—中西医结合]