基于中医传承辅助平台因地制宜探究北方肾性血尿病机规律  

An analysis of the pathogenesis of renal hematuria in Northern China according to the theory of taking actions that suit local circumstances based on Traditional Chinese Medicine Inheritance Support System

作　　者：刘恋 郭玲[2] 何学红[2] LIU Lian

机构地区：[1]辽宁中医药大学,辽宁沈阳110847 [2]辽宁中医药大学附属医院,辽宁沈阳110032

出　　处：《中医临床研究》2024年第17期64-67,共4页Clinical Journal Of Chinese Medicine

基　　金：辽宁省教育厅科学研究项目(L202031);辽宁省科学事业公益研究基金(2015001005);何学红全国名老中医药专家传承工作室建设项目(国中医药人教函[2022]75号)。

摘　　要：目的:运用中医传承辅助平台(V3.0)归纳治疗肾性血尿的用药,结合何学红教授经验验证分析北方地区肾性血尿病机规律。方法:于中国期刊全文数据库、万方数据库、维普数据库以及中国生物医学文献数据库等检索出2012年-2022年有关北方地区中医药治疗肾性血尿的文献,收集筛选相关方药录入中医传承辅助系统(V3.0)进行数据挖掘,对核心药物的频数、组方规律、关联规则等进行规律性分析。结果:对筛选出的112首方剂,共220味中药进行用药频次统计,获得19味用药频次≥20的中药,其中前5位分别为黄芪、小蓟、生地黄、白茅根、牡丹皮。四气五味分析得到处方中寒性及温性药物使用较多,五味分析发现甘味及苦味药使用频率最高。药物归经方面依次为肝经、肺经、肾经及脾经。药物关联规则分析确定常用药物组合18个,核心药物共12味,居前5位的组合分别是“黄芪、白术”“小蓟、白茅根”“生地黄、牡丹皮”“黄芪、山茱萸”和“墨旱莲、女贞子”。基于k均值聚类算法的组方规律分析得出核心组合4个。结论:基于中医传承辅助平台对北方地区中医药治疗肾性血尿的用药进行数据分析,结合何学红教授临床经验,验证北方地区肾性血尿病机多为脾肾两虚兼肝郁气滞,治疗上可在补益脾肾的同时佐以疏肝行气之药,为临床提供参考。Objective:The Traditional Chinese Medicine Inheritance Support System was used to summarize the drugs for the treatment of renal hematuria,and the pathogenesis of renal hematuria in Northern China was analyzed combined with the experience of Professor HE Xuehong.Methods:The literature on the treatment of renal hematuria in traditional Chinese medicine in Northern China from 2012 to 2022 was retrieved from CNKI,WANFANG,VIP and CBM.The relevant prescriptions were collected and screened and entered into Traditional Chinese Medicine Inheritance Support System(V3.0)for data mining.The frequency of core drugs,prescription rules and association rules were analyzed.Results:Based on the statistics of the drug frequency of 112 prescriptions and 220 traditional Chinese medicines,19 Chinese herbs with drug frequency not less than 20 were obtained,of which the top 5 were Huangqi(Radix Astragali),Xiaoji(Herba Cirsii),Shengdihuang(Radix Rehmanniae),Baimaogen(Rhizoma Imperatae),and Mudanpi(Cortex Moutan).Four Qi(气)and five-flavor analysis showed that cold and warm drugs were used more frequently in the prescription,while sweet and bitter drugs were used most frequently.The order of drug meridian is liver meridian,lung meridian,kidney meridian and spleen meridian.Drug association rule analysis identified 18 commonly used drug combinations,with a total of 12 core drugs.The top five combinations were Huangqi-Baizhu(Rhizoma Atractylodis Macrocephalae),Xiaoji-Baimaogen,Shengdihuang-Mudanpi,Huangqi-Shanzhuyu(Fructus Corni),Mohanlian(Herba Ecliptae)-Nvzhenzi(Fructus Ligustri Lucidi).Based on the analysis of the square rule of k-means clustering algorithm,four core combinations were obtained.Conclusion:Based on Traditional Chinese Medicine Inheritance Support System,the data analysis of TCM medicine in the treatment of renal hematuria in Northern China combined with Professor HE Xuehong’s clinical experience showed that the pathogenesis of renal hematuria in Northern China is mostly spleen and kidney deficiency and liver depression

关 键 词：肾性血尿 用药规律 北方地区 数据挖掘 

分 类 号：R256.5[医药卫生—中医内科学]